ArticleScientific reports2020
Time-resolved neurotransmitter detection in mouse brain tissue using an artificial intelligence-nanogap.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Integrating AI with Biosensors and Voltammetry for Neurotransmitter Detection and Quantification: A Systematic Review.Biosensors · 2025Pooled it
- Beyond ensemble averages: single-entity approaches for complex systems.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026Review
- Machine Learning for Neurotransmitter Monitoring by Fast Voltammetry: Current and Future Prospects.ACS chemical neuroscience · 2026Review
- Nanopore-Based Neurotransmitter Detection: Advances, Challenges, and Future Perspectives.ACS nano · 2025Review
- Artificial intelligence based advancements in nanomedicine for brain disorder management: an updated narrative review.Frontiers in medicine · 2025Review
- Single-Molecule Bioelectronic Sensors with AI-Aided Data Analysis: Convergence and Challenges.Precision chemistry · 2024Review
- Single-molecule detection of modified amino acid regulating transcriptional activity.RSC advances · 2024Article
- Direct biomolecule discrimination in mixed samples using nanogap-based single-molecule electrical measurement.Scientific reports · 2023Article
- Advances in single-molecule junctions as tools for chemical and biochemical analysis.Nature chemistry · 2023Review
- Direct observation of DNA alterations induced by a DNA disruptor.Scientific reports · 2022Article
- Mass spectrometry imaging of blast overpressure induced modulation of GABA/glutamate levels in the central auditory neuraxis of Chinchilla.Experimental and molecular pathology · 2021Article
- Development of Single-Molecule Electrical Identification Method for Cyclic Adenosine Monophosphate Signaling Pathway.Nanomaterials (Basel, Switzerland) · 2021Article
- Electrochemical Sensors Based on Conducting Polymers for the Aqueous Detection of Biologically Relevant Molecules.Nanomaterials (Basel, Switzerland) · 2021Review
- Single-Molecule Counting of Nucleotide by Electrophoresis with Nanochannel-Integrated Nano-Gap Devices.Micromachines · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The analysis of neurotransmitters in the brain helps to understand brain functions and diagnose Parkinson's disease. Pharmacological inhibition experiments, electrophysiological measurement of action potentials, and mass analysers have been applied for this purpose; however, these techniques do not allow direct neurotransmitter detection with good temporal resolution by using nanometre-sized electrodes. Hence, we developed a method for direct observation of a single neurotransmitter molecule with a gap width of ≤ 1 nm and on the millisecond time scale. It consists of measuring the tunnelling current that flows through a single-molecule by using nanogap electrodes and machine learning analysis. Using this method, we identified dopamine, serotonin, and norepinephrine neurotransmitters with high accuracy at the single-molecule level. The analysis of the mouse striatum and cerebral cortex revealed the order of concentration of the three neurotransmitters. Our method will be developed to investigate the neurotransmitter distribution in the brain with good temporal resolution.
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