Evidence map›Paper›PMID 32647340›Full record

ArticleActa pharmacologica Sinica2021

Increased S1P induces S1PR2 internalization to blunt the sensitivity of colorectal cancer to 5-fluorouracil via promoting intracellular uracil generation.

Yu-Hang Zhang, Shu-Xiang Cui, Sheng-Biao Wan, Shu-Hua Wu, Xian-Jun Qu

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmacologica Sinica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Yu-Hang ZhangDepartment of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Shu-Xiang CuiDepartment of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, China.
Sheng-Biao WanLaboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266100, China.
Shu-Hua WuDepartment of Pathology, Hospital of Binzhou Medical University, Binzhou 264003, China.
Xian-Jun QuDepartment of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China. qxj@sdu.edu.cn.
Capital Medical University · CNBinzhou Medical University · CNOcean University of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sphingosine-1-phosphate (S1P), the backbone of most sphingolipids, activating S1P receptors (S1PRs) and the downstream G protein signaling has been implicated in chemoresistance. In this study we investigated the role of S1PR2 internalization in 5-fluorouracil (5-FU) resistance in human colorectal cancer (CRC). Clinical data of randomly selected 60 CRC specimens showed the correlation between S1PR2 internalization and increased intracellular uracil (P < 0.001). Then we explored the regulatory mechanisms in CRC model of villin-S1PR2

Indexed as

Activating Transcription Factor 4AnimalsAntineoplastic AgentsColorectal NeoplasmsDrug Resistance, NeoplasmEndoplasmic ReticulumFemaleFluorouracilHCT116 CellsHumansLysophospholipidsMaleMiceMice, Inbred C57BLMiddle AgedRibonucleasesActivating Transcription Factor 4Antineoplastic AgentsATF4 protein, humanAtf4 protein, mouseFluorouracilLysophospholipidsRibonucleasesRNASET2 protein, humanS1PR2 protein, humanSphingosinesphingosine 1-phosphatesphingosine-1-phosphate receptor-2, mouseSphingosine-1-Phosphate ReceptorsTumor Suppressor ProteinsUracil5-FU resistancecolorectal cancerendoplasmic reticulum calcium ([Ca2+]ER)JTE-013S1PR2 internalizationsphingosine-1-phosphate (S1P)uracil generation

Identifiers

PMID32647340
PMCPMC8027438
OpenAlexW3041320010

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.