Evidence map›Paper›PMID 32647326›Full record

ArticleSpinal cord2021

Comparing outcomes of mechanical ventilation with high vs. moderate tidal volumes in tracheostomized patients with spinal cord injury in acute inpatient rehabilitation setting: a retrospective cohort study.

Radha Korupolu, Argyrios Stampas, Hannah Uhlig-Reche, Ellia Ciammaichella, Patrick John Mollett, Emmanuel Chigozie Achilike, Claudia Pedroza

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Spinal cord, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04912583 (Comparison of Mechanical Ventilation With Low and High Tidal Volumes in Acute Spinal Cord Injury), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04912583 nacompletednot on this map

Comparison of Mechanical Ventilation With Low and High Tidal Volumes in Acute Spinal Cord Injury: A Pilot Randomized Comparative Effectiveness Trial

TypeinterventionalSponsorThe University of Texas Health Science Center, HoustonRan2021 to 2024Enrolled31ConditionsSpinal Cord InjuriesArmsHigh tidal volume, Low tidal volume
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Radha KorupoluDepartment of Physical Medicine and Rehabilitation, McGovern Medical School, The University of Texas Health Science Center, Houston, TX, USA. Radha.korupolu@uth.tmc.edu.ORCID http://orcid.org/0000-0002-7419-6881
Argyrios StampasDepartment of Physical Medicine and Rehabilitation, McGovern Medical School, The University of Texas Health Science Center, Houston, TX, USA.
Hannah Uhlig-RecheDepartment of Physical Medicine and Rehabilitation, McGovern Medical School, The University of Texas Health Science Center, Houston, TX, USA.
Ellia CiammaichellaDivision of Physical Medicine and Rehabilitation, University of Utah, Salt Lake, UT, USA.
Patrick John MollettUS Physiatry, CHI Franciscan Rehabilitation Hospital, Tacoma, WA, USA.
Emmanuel Chigozie AchilikeDepartment of Physical Medicine and Rehabilitation, McGovern Medical School, The University of Texas Health Science Center, Houston, TX, USA.
Claudia PedrozaCenter for Clinical Research and Evidence Based Medicine (Biostatistician), The University of Texas Health Science Center, Houston, TX, USA.
The University of Texas Health Science Center at Houston · USCenter for Clinical Research (United States) · USFranciscan University of Steubenville · USThe University of Texas Health Science Center · USUniversity of Utah · US

Funding

Institutional Career Development CoreKL2TR003168 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MILLER, CHARLES C · 2019 to 2023
$4.9M
6 · The paper itself

Abstract

STUDY

designRetrospective cohort study.

objectivesThe primary objective of this study was to evaluate safety and efficacy of higher tidal volumes (HVt) compared to moderate Vt (MVt) in people with spinal cord injury (SCI) admitted to acute inpatient rehabilitation (AIR) facility on mechanical ventilation via tracheostomy.

settingAIR facility in the United States.

methodsEighty-four adults with SCI were divided into MVt group if maximum Vt received in AIR was <15 ml/kg predicted body weight (PBW) and HVt group if maximum Vt was >15 ml/kg PBW. Primary outcomes were incidence of pneumonia and composite pulmonary adverse events (pneumonia, weaning failure, or acute care transfers due to respiratory complications). Secondary outcomes were AIR preweaning days defined as time from AIR admission to beginning of weaning, weaning days defined as days from start to end of weaning, and AIR ventilator days calculated as days on ventilator from AIR admission to discharge.

resultsMVt was utilized in 50 patients and HVt was utilized in 34 patients. The risk of pneumonia in HVt group was 4.3 times higher [95% confidence interval (CI): 1.5-12] compared to MVt group. Odds of pulmonary adverse events in HVt group was 5.4 times higher (CI: 1.8-17) compared to MVt group. There was no difference in preweaning days, weaning days, or AIR ventilator days between the two groups.

conclusionsOur data suggest that HVt is associated with increased risk of pneumonia and higher odds of pulmonary adverse events in tracheostomized patients with SCI which warrants further investigation.

Indexed as

Respiration, ArtificialSpinal Cord InjuriesAdultHumansInpatientsRetrospective StudiesTidal VolumeVentilator Weaning

Identifiers

PMID32647326
OpenAlexW3040734479

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.