Evidence map›Paper›PMID 32647291›Full record

ArticleScientific reports2020

NIR multiphoton ablation of cancer cells, fluorescence quenching and cellular uptake of dansyl-glutathione-coated gold nanoparticles.

Antonio Buonerba, Rosita Lapenta, Anna Donniacuo, Magda Licasale, Elena Vezzoli, Stefano Milione, Carmine Capacchione, Mario Felice Tecce, Andrea Falqui, Roberto Piacentini and 2 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07732933 (GSK-3 as a Target for Lithium-charged Au Nanoparticles in Bipolar Disorder), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07732933 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

GSK-3 as a Target for Lithium-charged Au Nanoparticles in Bipolar Disorder

TypeinterventionalSponsorFondazione Policlinico Universitario Agostino Gemelli IRCCSRan2026 to 2029Enrolled20ConditionsBipolar Disorder (BD), Bipolar Disorder (BPD)ArmsPeripheral blood sampling for PBMC isolation
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Antonio BuonerbaSanitary Environmental Engineering Division (SEED), and Consorzio Inter-universitario Previsione e Prevenzione dei Grandi Rischi (Cu.G.Ri.), Department of Civil Engineering, University of Salerno, Via Giovanni Paolo II, 84084, Fisciano, SA, Italy. abuonerba@unisa.it.ORCID http://orcid.org/0000-0003-1101-3248
Rosita LapentaDepartment of Chemistry and Biology "Adolfo Zambelli", University of Salerno, Via Giovanni Paolo II, 84084, Fisciano, SA, Italy.
Anna DonniacuoDepartment of Chemistry and Biology "Adolfo Zambelli", University of Salerno, Via Giovanni Paolo II, 84084, Fisciano, SA, Italy.
Magda LicasaleDepartment of Chemistry and Biology "Adolfo Zambelli", University of Salerno, Via Giovanni Paolo II, 84084, Fisciano, SA, Italy.
Elena VezzoliBiological and Environmental Sciences and Engineering (BESE) Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.
Stefano MilioneDepartment of Chemistry and Biology "Adolfo Zambelli", University of Salerno, Via Giovanni Paolo II, 84084, Fisciano, SA, Italy.
Carmine CapacchioneDepartment of Chemistry and Biology "Adolfo Zambelli", University of Salerno, Via Giovanni Paolo II, 84084, Fisciano, SA, Italy.ORCID http://orcid.org/0000-0001-7254-8620
Mario Felice TecceDepartment of Pharmacy, University of Salerno, Via Giovanni Paolo II, 84084, Fisciano, SA, Italy.ORCID http://orcid.org/0000-0003-2355-6047
Andrea FalquiBiological and Environmental Sciences and Engineering (BESE) Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia. andrea.falqui@kaust.edu.sa.ORCID http://orcid.org/0000-0002-1476-7742
Roberto PiacentiniDepartment of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy. roberto.piacentini@unicatt.it.
Claudio GrassiDepartment of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy.
Alfonso GrassiDepartment of Chemistry and Biology "Adolfo Zambelli", University of Salerno, Via Giovanni Paolo II, 84084, Fisciano, SA, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Theranostics based on two-photon excitation of therapeutics in the NIR region is an emerging and powerful tool in cancer therapy since this radiation deeply penetrates healthy biological tissues and produces selective cell death. Aggregates of gold nanoparticles coated with glutathione corona functionalized with the dansyl chromophore (a-DG-AuNPs) were synthesized and found efficient nanodevice for applications in photothermal therapy (PTT). Actually the nanoparticle aggregation enhances the quenching of radiative excitation and the consequent conversion into heat. The a-DG-AuNPs are readily internalized in Hep G2 where the chromophore acts as both antenna and transducer of the NIR radiation under two-photons excitation, determining efficient cell ablation via photothermal effect.

Indexed as

AnimalsCell Line, TumorCombined Modality TherapyFluorescenceGlutathioneGoldHumansInfrared RaysLasersLow-Level Light TherapyMetal NanoparticlesMiceNeoplasmsPhosphatidylcholinesPhotonsPhotothermal Therapy1-myristoyl-2-(12-((5-dimethylamino-1-naphthalenesulfonyl)amino)dodecanoyl)-sn-glycero-3-phosphocholineGlutathioneGoldPhosphatidylcholines

Identifiers

PMID32647291
PMCPMC7347844

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.