Evidence map›Paper›PMID 32647259›Full record

ArticleScientific reports2020

Nanosensors based on LSPR are able to serologically differentiate dengue from Zika infections.

Alice F Versiani, Estefânia M N Martins, Lidia M Andrade, Laura Cox, Glauco C Pereira, Edel F Barbosa-Stancioli, Mauricio L Nogueira, Luiz O Ladeira, Flávio G da Fonseca

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In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  6. Direct Detection ofSensors (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alice F VersianiLaboratório de Virologia Básica e Aplicada, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Estefânia M N MartinsLaboratório de Química de Nanoestruturas de Carbono, Centro de Desenvolvimento da Tecnologia Nuclear-CDTN/CNEN, Belo Horizonte, MG, Brazil.
Lidia M AndradeLaboratório de Nanomateriais, Departamento de Física, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.ORCID http://orcid.org/0000-0003-2594-4617
Laura CoxLaboratório de Virologia Básica e Aplicada, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Glauco C PereiraFundacao Ezequiel Dias, FUNED, Belo Horizonte, MG, Brazil.
Edel F Barbosa-StancioliLaboratório de Virologia Básica e Aplicada, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.ORCID http://orcid.org/0000-0001-6584-4333
Mauricio L NogueiraLaboratório de Pesquisa em Virologia, Departamento de Doenças Infecciosas e Parasitárias, Faculdade de Medicina de São José Do Rio Preto, São José do Rio Preto, SP, Brazil.ORCID http://orcid.org/0000-0003-1102-2419
Luiz O LadeiraLaboratório de Nanomateriais, Departamento de Física, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Flávio G da FonsecaLaboratório de Virologia Básica e Aplicada, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. dafonseca@icb.ufmg.br.ORCID http://orcid.org/0000-0002-1416-8694

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Flaviviridae virus family was named after the Yellow-fever virus, and the latin term flavi means "of golden color". Dengue, caused by Dengue virus (DENV), is one of the most important infectious diseases worldwide. A sensitive and differential diagnosis is crucial for patient management, especially due to the occurrence of serological cross-reactivity to other co-circulating flaviviruses. This became particularly important with the emergence of Zika virus (ZIKV) in areas were DENV seroprevalence was already high. We developed a sensitive and specific diagnostic test based on gold nanorods (GNR) functionalized with DENV proteins as nanosensors. These were able to detect as little as one picogram of anti-DENV monoclonal antibodies and highly diluted DENV-positive human sera. The nanosensors could differentiate DENV-positive sera from other flavivirus-infected patients, including ZIKV, and were even able to distinguish which DENV serotype infected individual patients. Readouts are obtained in ELISA-plate spectrophotometers without the need of specific devices.

Indexed as

Antibodies, ViralBiosensing TechniquesBrazilCohort StudiesDengueGoldHumansMetal NanoparticlesSeroepidemiologic StudiesSurface Plasmon ResonanceViral Envelope ProteinsZika Virus InfectionAntibodies, ViralGoldViral Envelope Proteins

Identifiers

PMID32647259
PMCPMC7347616

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.