Evidence map›Paper›PMID 32647210›Full record

ArticleScientific reports2020

Regional transcriptome analysis of AMPA and GABA

Kevin Shen, Tommaso Zeppillo, Agenor Limon

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Sex-Dependent Modulation of AMPA and GABACurrent neuropharmacology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Kevin Shen *Gladstone Institute of Neurological Disease, University of California, San Francisco, USA.
Tommaso Zeppillo *Department of Life Sciences, B.R.A.I.N., Centre for Neuroscience, University of Trieste, Trieste, Italy.
Agenor LimonDepartment of Neurology, Mitchell Center for Neurodegenerative Diseases, School of Medicine, University of Texas Medical Branch, 10.138B. Medical Research Building, Galveston, TX, 77555, USA. aglimonr@utmb.edu.ORCID http://orcid.org/0000-0002-6613-770X
Gladstone Institutes · USThe University of Texas Medical Branch at Galveston · USUniversity of Trieste · IT

Funding

Synaptic Imbalance in Mild Cognitive Impairment and Alzheimer's DiseaseR21AG053740 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LAUTERBORN, JULIE C, LIMON, AGENOR · 2016 to 2017
$425k
Multidimensional Analysis of Synaptic Dysfunction in SchizophreniaR21MH113177 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIMON, AGENOR, VAWTER, MARQUIS PHILIP · 2017 to 2018
$425k
NIA NIH HHS AG053740NIA NIH HHS R21 AG053740NIMH NIH HHS MH113177NIMH NIH HHS R21 MH113177
6 · The paper itself

Abstract

Theoretical and experimental work has demonstrated that excitatory (E) and inhibitory (I) currents within cortical circuits stabilize to a balanced state. This E/I balance, observed from single neuron to network levels, has a fundamental role in proper brain function and its impairment has been linked to numerous brain disorders. Over recent years, large amount of microarray and RNA-Sequencing datasets have been collected, however few studies have made use of these resources for exploring the balance of global gene expression levels between excitatory AMPA receptors (AMPARs) and inhibitory GABA

Indexed as

AnimalsBrainDatasets as TopicExcitatory Postsynaptic PotentialsHumansInhibitory Postsynaptic PotentialsMiceNeuronsOligonucleotide Array Sequence AnalysisProtein SubunitsReceptors, AMPAReceptors, GABA-ARNA-SeqTranscriptomeProtein SubunitsReceptors, AMPAReceptors, GABA-A

Identifiers

PMID32647210
PMCPMC7347860
OpenAlexW3041358491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.