ArticleScientific reports2020
Silencing miR-370-3p rescues funny current and sinus node function in heart failure.
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Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32citing papers in PubMed
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32 citing papers in PubMed, 49 citations in OpenAlex.
- Transcriptomic Profiling of MicroRNA and Non-Coding RNA from Whole Blood of African Americans with MASLD.International journal of molecular sciences · 2026Article
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- CPT1a Expression Is a Critical Cardioprotective Response to Pathological Stress That Enables Rescue by Gene Transfer.Circulation research · 2026Article
- Anticoagulation Therapies and microRNAs in Heart Failure.Biomolecules · 2025Review
- The Hidden Regulators: MicroRNAs in Pediatric Heart Development and Disease.Journal of clinical medicine · 2025Review
- Epigenetic Mechanisms in Heart Diseases.Reviews in cardiovascular medicine · 2025Review
- Aging and sinus node dysfunction: mechanisms and future directions.Clinical science (London, England : 1979) · 2025Review
- Article
- Advances in MicroRNA Therapy for Heart Failure: Clinical Trials, Preclinical Studies, and Controversies.Cardiovascular drugs and therapy · 2025Review
- Feline hypertrophic cardiomyopathy: Does the microRNA-mRNA regulatory network contribute to heart sarcomeric protein remodelling?International journal of experimental pathology · 2024Article
- Proteomics couples electrical remodelling to inflammation in a murine model of heart failure with sinus node dysfunction.Cardiovascular research · 2024Article
- MicroRNAs: Midfielders of Cardiac Health, Disease and Treatment.International journal of molecular sciences · 2023Review
- Non-Coding RNAs and Gut Microbiota in the Pathogenesis of Cardiac Arrhythmias: The Latest Update.Genes · 2023Review
- YAP/TAZ: Molecular pathway and disease therapy.MedComm · 2023Review
- Circular RNA as Therapeutic Targets in Atherosclerosis: Are We Running in Circles?Journal of clinical medicine · 2023Review
- Remodelling and dysfunction of the sinus node in pulmonary arterial hypertension.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Noncoding RNAs as Key Regulators for Cardiac Development and Cardiovascular Diseases.Journal of cardiovascular development and disease · 2023Review
- Atrioventricular node dysfunction in pressure overload-induced heart failure-Involvement of the immune system and transcriptomic remodelling.Frontiers in pharmacology · 2023Article
- Heart failure in mice induces a dysfunction of the sinus node associated with reduced CaMKII signaling.The Journal of general physiology · 2022Article
- Micro RNA-411 Expression Improves Cardiac Phenotype Following Myocardial Infarction in Mice.JACC. Basic to translational science · 2022Article
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Authors and funding
28 authors at 5 institutions in 4 countries.
Joseph Yanni *Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.
Alicia D'Souza *Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.
Yanwen WangDivision of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.
Ning LiPhysiology and Cell Biology, Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.ORCID http://orcid.org/0000-0002-7595-3418
Brian J HansenPhysiology and Cell Biology, Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Stanislav O ZakharkinPhysiology and Cell Biology, Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.ORCID http://orcid.org/0000-0001-9816-510X
Matthew SmithDivision of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.ORCID http://orcid.org/0000-0002-4078-8352
Christina HaywardDivision of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.ORCID http://orcid.org/0000-0003-3828-7126
Bryan A WhitsonBob and Corrine Frick Center for Heart Failure and Arrhythmia Research and Dorothy M. Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH, 43210, USA.ORCID http://orcid.org/0000-0003-0040-3638
Peter J MohlerPhysiology and Cell Biology, Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Paul M L JanssenPhysiology and Cell Biology, Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.ORCID http://orcid.org/0000-0002-9682-3014
Leo ZeefBioinformatics Core Facility, University of Manchester, Manchester, UK.
Moinuddin ChoudhuryDivision of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.
Min ZiDivision of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.
Xue CaiDivision of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.
Sunil Jit R J LoganthaDivision of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.ORCID http://orcid.org/0000-0001-8994-2296
Shu NakaoDivision of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.ORCID http://orcid.org/0000-0001-8990-1179
Andrew AtkinsonDivision of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.
Maria PetkovaDivision of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.
Ursula DorisDivision of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.
Jonathan AriyaratnamDivision of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.
Elizabeth J CartwrightDivision of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.
Sam Griffiths-JonesDivision of Evolution and Genomics Sciences, University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0001-6043-807X
George HartDivision of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.
Vadim V FedorovPhysiology and Cell Biology, Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Delvac OceandyDivision of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.ORCID http://orcid.org/0000-0002-6242-6491
Halina DobrzynskiDivision of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.ORCID http://orcid.org/0000-0003-4754-5975
Mark R BoyettDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 2200N, Copenhagen, Denmark. mark.boyett@sund.ku.dk.ORCID http://orcid.org/0000-0003-3931-2020
University of Manchester · GBThe Ohio State University Wexner Medical Center · USJagiellonian University · PLUniversity of Copenhagen · DKUniversity of Liverpool · GB
Funding
Defining novel mechanisms for human arrhythmiaR35HL135754 · NHLBI · OHIO STATE UNIVERSITY · PI MOHLER, PETER J. · 2017 to 2023
$6.0MTargeting the Arrhythmogenic Sources of Human Atrial FibrillationR01HL135109 · NHLBI · OHIO STATE UNIVERSITY · PI Vadim V Fedorov · 2017 to 2026
$6.0MFrequency-dependent modulation of cardiac myofilament function in health/diseaseR01HL113084 · NHLBI · OHIO STATE UNIVERSITY · PI JANSSEN, PAULUS ML · 2012 to 2023
$4.6MIntegration of structure and signaling in cardiac pacemaker functionR01HL115580 · NHLBI · OHIO STATE UNIVERSITY · PI FEDOROV, VADIM V · 2013 to 2021
$4.2MDefining novel mechanisms for regulation of atrial INa and arrhythmiasR01HL134824 · NHLBI · OHIO STATE UNIVERSITY · PI HUND, THOMAS JEFFREY, MOHLER, PETER J. · 2017 to 2020
$3.0MBritish Heart Foundation FS/19/1/34035British Heart Foundation RG/18/2/33392Medical Research Council MR/P015816/1NHLBI NIH HHS R01 HL113084NHLBI NIH HHS R01 HL115580NHLBI NIH HHS R01 HL134824NHLBI NIH HHS R01 HL135109NHLBI NIH HHS R35 HL135754NIH HHS HL115580NIH HHS HL135109
Abstract
Bradyarrhythmias are an important cause of mortality in heart failure and previous studies indicate a mechanistic role for electrical remodelling of the key pacemaking ion channel HCN4 in this process. Here we show that, in a mouse model of heart failure in which there is sinus bradycardia, there is upregulation of a microRNA (miR-370-3p), downregulation of the pacemaker ion channel, HCN4, and downregulation of the corresponding ionic current, I
Indexed as
Gene SilencingAnimalsBinding SitesBody WeightCardiomegalyComputational BiologyDown-RegulationFibrosisHeart FailureHeart RateHumansHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMaleMiceMice, Inbred C57BLMicroRNAsHcn4 protein, mouseHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMicroRNAsMIRN370 microRNA, humanMIRN370 microRNA, mouseMIRN370 microRNA, rat
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.