Evidence map›Paper›PMID 32647095›Full record

ReviewBiomedical materials (Bristol, England)2020

Emerging local delivery strategies to enhance bone regeneration.

Satheesh Elangovan, Praveen Gajendrareddy, Sriram Ravindran, Aliasger K Salem

Abstract readReview
In one paragraph

Review in Biomedical materials (Bristol, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Emerging roles of exosomes in oral diseases progression.International journal of oral science · 2024
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Satheesh ElangovanDepartment of Periodontics, The University of Iowa College of Dentistry, Iowa City, IA 52242, United States of America.ORCID 0000-0001-5740-6026
Praveen GajendrareddyDepartment of Periodontics, The University of Illinois at Chicago College of Dentistry, Chicago, IL 60612, United States of America.
Sriram RavindranDepartment of Oral Biology, The University of Illinois at Chicago College of Dentistry, Chicago, IL 60612, United States of America.
Aliasger K SalemDepartment of Pharmaceutical Sciences and Experimental Therapeutics, The University of Iowa College of Pharmacy, Iowa City, IA 52242, United States of America.

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Functional Activation and Targeting of Exosomes for Regenerative MedicineR01DE027404 · NIDCR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GAJENDRAREDDY, PRAVEEN, RAVINDRAN, SRIRAM · 2018 to 2022
$2.1M
A Novel RNA Based Biomaterial for Bone RegenerationR21DE024206 · NIDCR · UNIVERSITY OF IOWA · PI ELANGOVAN, SATHEESH · 2015 to 2016
$406k
NIDCR NIH HHS R01 DE027404NIDCR NIH HHS R21 DE024206NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

In orthopedics and dentistry there is an increasing need for novel biomaterials and clinical strategies to achieve predictable bone regeneration. These novel molecular strategies have the potential to eliminate the limitations of currently available approaches. Specifically, they have the potential to reduce or eliminate the need to harvest autogenous bone, and the overall complexity of the clinical procedures. In this review, emerging tissue engineering strategies that have been, or are currently being, developed based on the current understanding of bone biology, development and wound healing will be discussed. In particular, protein/peptide based approaches, DNA/RNA therapeutics, cell therapy, and the use of exosomes will be briefly covered. The review ends with a summary of the current status of these approaches, their clinical translational potentials and their challenges.

Indexed as

Bone RegenerationAnimalsBiocompatible MaterialsBone and BonesDNAExosomesGenetic TherapyHumansLipidsOrthopedicsProteinsRegenerationRNATissue EngineeringTissue ScaffoldsTranslational Research, BiomedicalBiocompatible MaterialsDNALipidsProteinsRNA

Identifiers

PMID32647095
PMCPMC10148649

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.