ArticleProceedings of the National Academy of Sciences of the United States of America2020
Identification of the initial nucleocapsid recognition element in the HIV-1 RNA packaging signal.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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50citing papers in PubMed
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Who cites it
50 citing papers in PubMed.
- Article
- 5' leader defects drive persistent HIV-1 viremia on long-term ART.Nature communications · 2026Article
- The biased adenosine-rich content of the HIV-1 genome serves as a molecular signature that facilitates efficient packaging.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication.FEMS microbiology reviews · 2026Review
- Research progress on HIV-1 structural proteins and antiviral therapies.Frontiers in immunology · 2026Review
- Controlling nanocage assembly, towards developing a one-health "plug & play" platform for targeted therapy.Chemical communications (Cambridge, England) · 2025Review
- Mapping HIV-1 RNA structure, homodimers, long-range interactions and persistent domains by HiCapR.eLife · 2025Article
- Optimized Preparation of Segmentally Labeled RNAs for NMR Structure Determination.Journal of molecular biology · 2025Article
- Elements in the 5' Untranslated Region of Viral RNA Important for HIV Gag Recognition and Cross-Packaging.Viruses · 2025Article
- Review
- The role of structure in regulatory RNA elements.Bioscience reports · 2024Review
- Transcription start site choice regulates HIV-1 RNA conformation and function.Current opinion in structural biology · 2024Review
- Role of RNA structural plasticity in modulating HIV-1 genome packaging and translation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Recruitment of multi-segment genomic RNAs by Bluetongue virus requires a preformed RNA network.Nucleic acids research · 2024Article
- HIV-1 RNA genome packaging: it's G-rated.mBio · 2024Review
- Reverse transcription of plasma-derived HIV-1 RNA generates multiple artifacts through tRNA(Lys-3)-priming.Microbiology spectrum · 2024Article
- Roles of RNA scaffolding in nanoscale Gag multimerization and selective protein sorting at HIV membranes.Science advances · 2024Article
- Conformational transitions of the HIV-1 Gag polyprotein upon multimerization and gRNA binding.Biophysical journal · 2024Article
- Learning from Persistent Viremia: Mechanisms and Implications for Clinical Care and HIV-1 Cure.Current HIV/AIDS reports · 2023Review
- Nano-DMS-MaP allows isoform-specific RNA structure determination.Nature methods · 2023Article
Corrections and comments
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Authors and funding
17 authors.
Pengfei DingDepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250.ORCID 0000-0003-1824-724X
Siarhei KharytonchykDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109.
Alexis WallerDepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250.ORCID 0000-0002-1435-7911
Ugonna MbaekweDepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250.
Sapna BasappaDepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250.
Nansen KuoDepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250.
Heather M FrankDepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250.
Christina QuasneyDepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250.
Aaron KidaneDepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250.
Canessa SwansonDepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250.ORCID 0000-0002-8005-7562
Verna VanDepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250.
Mitali SarkarDepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250.
Emily CannistraciDepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250.ORCID 0000-0003-1880-9185
Ridhi ChaudharyDepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250.ORCID 0000-0003-0387-6342
Hana FloresDepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250.
Alice TelesnitskyDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109 ateles@umich.edu summers@hhmi.umbc.edu.ORCID 0000-0001-9878-5931
Michael F SummersDepartment of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250; ateles@umich.edu summers@hhmi.umbc.edu.ORCID 0000-0003-4267-4380
Funding
The MARC U*STAR Program at UMBCT34GM008663 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI ROBINSON, PHYLLIS R · 1997 to 2019
$21.9MEXPAND PARTICIPATION BY MINORITIES IN BIOMEDICAL SCIENCER25GM055036 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI SUMMERS, MICHAEL FINLEY · 1996 to 2021
$16.9MThe Center for HIV RNA Studies (CRNA)U54AI150470 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BIENIASZ, PAUL D. · 2019 to 2021
$15.1MU-RISE at University of Maryland Baltimore CountyT34GM136497 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI PHYLLIS R ROBINSON · 2020 to 2026
$9.5M STEM BUILD@UMBC: Student Training CoreTL4GM118989 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI LACOURSE, WILLIAM RICHARD · 2015 to 2023
$8.5MSTEM BUILD@UMBC: Overall ComponentUL1GM118988 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI LACOURSE, WILLIAM RICHARD · 2015 to 2023
$6.6MNMR Studies of Retroviral Nucleic Acid Binding ProteinsR01AI150498 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI MICHAEL FINLEY SUMMERS · 2020 to 2026
$5.1MTraining in Cardiovascular Translational ResearchT32HL120826 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT, TABAS, IRA A · 2014 to 2023
$4.7MSTEM BUILD@UMBC: Research Enrichment CoreRL5GM118987 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI LACOURSE, WILLIAM RICHARD · 2015 to 2023
$2.6M STEM BUILD@UMBC: Student Training CoreTL4MD009632 · NIMHD · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI LACOURSE, WILLIAM RICHARD, ROUS, PHILIP J · 2014 to 2014
$1.0MHoward Hughes Medical InstituteNHLBI NIH HHS T32 HL120826NIAID NIH HHS R01 AI150498NIAID NIH HHS U54 AI150470NIGMS NIH HHS R25 GM055036NIGMS NIH HHS RL5 GM118987NIGMS NIH HHS T34 GM008663NIGMS NIH HHS T34 GM136497NIGMS NIH HHS TL4 GM118989NIGMS NIH HHS UL1 GM118988NIMHD NIH HHS TL4 MD009632
Abstract
Selective packaging of the HIV-1 genome during virus assembly is mediated by interactions between the dimeric 5'-leader of the unspliced viral RNA and the nucleocapsid (NC) domains of a small number of assembling viral Gag polyproteins. Here, we show that the dimeric 5'-leader contains more than two dozen NC binding sites with affinities ranging from 40 nM to 1.4 μM, and that all high-affinity sites (
Indexed as
Regulatory Sequences, Ribonucleic AcidRNA, ViralVirus AssemblyBase SequenceBinding SitesGenome, ViralHIV-1HIV InfectionsNucleic Acid ConformationNucleocapsidNucleocapsid ProteinsProtein BindingNucleocapsid ProteinsRegulatory Sequences, Ribonucleic AcidRNA, ViralgenomeHIV-1nucleocapsidpackagingRNA
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.