Evidence map›Paper›PMID 32647059›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Prototypical pacemaker neurons interact with the resident microbiota.

Alexander Klimovich, Stefania Giacomello, Åsa Björklund, Louis Faure, Marketa Kaucka, Christoph Giez, Andrea P Murillo-Rincon, Ann-Sophie Matt, Doris Willoweit-Ohl, Gabriele Crupi and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
  2. Review
  3. Diffuse pacemaker mechanism with distinctive organization drives pulsation in the octocoralProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Sleeping upside-down: Knockdown of a sleep-associated gene induces daytime sleep in the jellyfishProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Assembly of a functional neuronal circuit in embryos of an ancestral metazoan is influenced by temperature and the microbiome.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Review
  8. Dynamics of neural activity in early nervous system evolution.Current opinion in behavioral sciences · 2024
    Article
  9. Article
  10. Novel technologies uncover novel 'anti'-microbial peptides inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Article
  11. Review
  12. Article
  13. Article
  14. A complete biomechanical model ofProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  15. Article
  16. Microorganisms · 2022
    Article
  17. Article
  18. Symbiotic Algae ofFrontiers in microbiology · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 5 countries.

Alexander KlimovichDepartment of Cell and Developmental Biology, Zoological Institute, University of Kiel, D-24118 Kiel, Germany; aklimovich@zoologie.uni-kiel.de tbosch@zoologie.uni-kiel.de.ORCID 0000-0003-1764-0613
Stefania GiacomelloDepartment of Biochemistry and Biophysics, National Infrastructure of Sweden, Science for Life Laboratory, Stockholm University, 17121 Solna, Sweden.ORCID 0000-0003-0738-1574
Åsa BjörklundDepartment of Cell and Molecular Biology, National Infrastructure of Sweden, Science for Life Laboratory, Uppsala University, 75237 Uppsala, Sweden.
Louis FaureDepartment of Molecular Neurosciences, Center for Brain Research, Medical University Vienna, 1090 Vienna, Austria.ORCID 0000-0003-4621-586X
Marketa KauckaDepartment of Molecular Neurosciences, Center for Brain Research, Medical University Vienna, 1090 Vienna, Austria.
Christoph GiezDepartment of Cell and Developmental Biology, Zoological Institute, University of Kiel, D-24118 Kiel, Germany.ORCID 0000-0002-8101-6498
Andrea P Murillo-RinconDepartment of Cell and Developmental Biology, Zoological Institute, University of Kiel, D-24118 Kiel, Germany.
Ann-Sophie MattDepartment of Cell and Developmental Biology, Zoological Institute, University of Kiel, D-24118 Kiel, Germany.
Doris Willoweit-OhlDepartment of Cell and Developmental Biology, Zoological Institute, University of Kiel, D-24118 Kiel, Germany.ORCID 0000-0003-1693-5057
Gabriele CrupiDepartment of Cell and Developmental Biology, Zoological Institute, University of Kiel, D-24118 Kiel, Germany.
Jaime de AndaDepartment of Bioengineering, California NanoSystems Institute, University of California, Los Angeles, CA 90095-1600.ORCID 0000-0003-2129-0775
Gerard C L WongDepartment of Bioengineering, California NanoSystems Institute, University of California, Los Angeles, CA 90095-1600.ORCID 0000-0003-0893-6383
Mauro D'AmatoSchool of Biological Sciences, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0003-2743-5197
Igor AdameykoDepartment of Molecular Neurosciences, Center for Brain Research, Medical University Vienna, 1090 Vienna, Austria.ORCID 0000-0001-5471-0356
Thomas C G BoschDepartment of Cell and Developmental Biology, Zoological Institute, University of Kiel, D-24118 Kiel, Germany; aklimovich@zoologie.uni-kiel.de tbosch@zoologie.uni-kiel.de.ORCID 0000-0002-9488-5545
Christian-Albrechts-Universität zu Kiel · DECalifornia NanoSystems Institute · USKarolinska Institutet · SEMedical University of Vienna · ATMonash University · AUStockholm University · SEUppsala University · SE

Funding

Austrian Science Fund FWF DOC 33European Research Council 647844
6 · The paper itself

Abstract

Pacemaker neurons exert control over neuronal circuit function by their intrinsic ability to generate rhythmic bursts of action potential. Recent work has identified rhythmic gut contractions in human, mice, and hydra to be dependent on both neurons and the resident microbiota. However, little is known about the evolutionary origin of these neurons and their interaction with microbes. In this study, we identified and functionally characterized prototypical ANO/SCN/TRPM ion channel-expressing pacemaker cells in the basal metazoan

Indexed as

Biological ClocksMicrobiotaAction PotentialsAnimalsBiological EvolutionCluster AnalysisComputational BiologyGene Expression ProfilingGene Expression RegulationGenome-Wide Association StudyHumansHydraMiceNeuronsantimicrobial peptideHydraion channelmicrobiomepacemaker neuron

Identifiers

PMID32647059
PMCPMC7395494
OpenAlexW3041921093

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.