SynthesisBMJ open2020
Anxiety and clinical outcomes of patients with acute coronary syndrome: a meta-analysis.
Synthesis in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pooled it
- Prevalence of anxiety and depression in patients with acute coronary syndrome: systematic review and meta-analysis.The Pan African medical journal · 2023Pooled it
- Anxiety is associated with higher recurrence of atrial fibrillation after catheter ablation: A meta-analysis.Clinical cardiology · 2022Pooled it
- Anxiety and prognosis of patients with myocardial infarction: A meta-analysis.Clinical cardiology · 2021Pooled it
- Evaluating the effect of a smartphone-based self-help intervention on the quality of life of patients with acute coronary syndrome.BMC cardiovascular disorders · 2025Trial
- Combined Prognostic Value of Triglyceride-Glucose Index and Bilirubin in Drug-Eluting Stent Restenosis: From Clinical Risk Stratification to Exploratory Vascular-Cell Findings.Cardiovascular drugs and therapy · 2026Article
- Guideline-directed Low-density Lipoprotein Cholesterol Management After Acute Coronary Syndrome in Patients With Mental Illness: a Population-based Study.Cardiovascular drugs and therapy · 2026Article
- Longitudinal Psychosocial and Sleep Assessments for Long-Term Cardiovascular Risk Stratification after First Myocardial Infarction in Rural India.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026Article
- Anxiety and peripheral artery disease.Clinical science (London, England : 1979) · 2026Review
- Psychological Burden and Psychosocial Stress in Younger and Middle-Aged Women with Prior Myocardial Infarction.Medicina (Kaunas, Lithuania) · 2026Article
- The Mental Health-Acute Coronary Syndrome Continuum: Bidirectional Pathophysiological Links and Clinical Implications.Medical sciences (Basel, Switzerland) · 2026Review
- Impact of continuous home care on quality of life and depression status in patients with acute coronary syndrome.Frontiers in cardiovascular medicine · 2026Article
- Serotonin Norepinephrine Reuptake Inhibitor Is Associated With Lower Mortality Among Patients Presenting With Takotsubo Cardiomyopathy.Journal of the American Heart Association · 2025Article
- Investigating psychological difference between two genders in mental health after percutaneous coronary intervention for elderly patients with acute coronary syndrome.Journal of cardiothoracic surgery · 2025Article
- Anxiety, a significant risk factor for coronary artery disease: what is the best index.BMC psychiatry · 2024Article
- Psychological impact of first admission with cardiovascular disease in a tertiary hospital in Oman.Journal of Taibah University Medical Sciences · 2024Article
- Anxiety and depression in patients aged 80 years and older following aortic valve therapy. A six-month follow-up study.Aging clinical and experimental research · 2023Article
- Prevalence of posttraumatic stress disorder following acute coronary syndrome and clinical characteristics of patients referred to cardiac rehabilitation.World journal of psychiatry · 2023Article
- Effects of Plant-Emitted Monoterpenes on Anxiety Symptoms: A Propensity-Matched Observational Cohort Study.International journal of environmental research and public health · 2023Observational
- Impact of mental disorders on clinical outcomes of physical diseases: an umbrella review assessing population attributable fraction and generalized impact fraction.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAnxiety has been suggested to be associated with poor outcomes in patients with acute coronary syndrome (ACS). However, results of previous follow-up studies were inconsistent. The aim of this meta-analysis was to evaluate the association between anxiety and clinical outcomes in patients with ACS, and to investigate the potential role of depression underlying the above association.
designA meta-analysis of prospective follow-up studies.
settingHospitals.
participantsPatients with ACS.
interventionsWe included related prospective follow-up studies up through 20 July 2019 that were identified by searching PubMed and Embase databases. A random-effect model was used for the meta-analysis. Anxiety was evaluated by validated instruments at baseline. PRIMARY AND SECONDARY OUTCOME MEASURES: We determined the association between anxiety and risks of mortality and adverse cardiovascular events (MACEs) in patients with ACS.
resultsOur analysis included 17 studies involving 39 038 patients wqith ACS. Anxiety was independently associated with increased mortality risk (adjusted risk ratio (RR) 1.21, 95% CI 1.07 to 1.37, p=0.002) and MACEs (adjusted RR 1.47, 95% CI 1.24 to 1.74, p<0.001) in patients with ACS. Subgroup analyses showed that depression may at least partly confound the association between anxiety and poor outcomes in patients with ACS. Adjustment of depression significantly attenuated the association between anxiety and MACEs (adjusted RR 1.25, 95% CI 1.04 to 1.52, p=0.02). Moreover, anxiety was not significantly associated with mortality risk after adjusting for depression (adjusted RR 0.88, 95% CI 0.66 to 1.17, p=0.37).
conclusionsAnxiety is associated with increased risk of mortality and MACEs in patients with ACS. However, at least part of the association may be confounded by concurrent depressive symptoms in these patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.