Evidence map›Paper›PMID 32647008›Full record

ArticleThe Journal of biological chemistry2020

Motoneuron expression profiling identifies an association between an axonal splice variant of HDGF-related protein 3 and peripheral myelination.

Bilal Ersen Kerman, Stéphane Genoud, Burcu Kurt Vatandaslar, Ahmet Murat Denli, Shereen Georges Ghosh, Xiangdong Xu, Gene W Yeo, James Bradley Aimone, Fred H Gage

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Bilal Ersen KermanDepartment of Histology and Embryology, Istanbul Medipol University International School of Medicine, Istanbul, Turkey; Regenerative and Restorative Medicine Research Center, Institute of Health Science, Department of Neuroscience, Istanbul Medipol University, Istanbul, Turkey; Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California, USA.
Stéphane GenoudLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California, USA; Vifor Pharma, Villars-sur-Glâne, Switzerland.
Burcu Kurt VatandaslarRegenerative and Restorative Medicine Research Center, Institute of Health Science, Department of Neuroscience, Istanbul Medipol University, Istanbul, Turkey; Institute of Health Science, Department of Neuroscience, Istanbul Medipol University, Istanbul, Turkey.
Ahmet Murat DenliLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California, USA.
Shereen Georges GhoshLaboratory for Pediatric Brain Disease, University of California, San Diego, La Jolla, California, USA; Rady Children's Institute for Genomic Medicine, Rady Children's Hospital, San Diego, California, USA.
Xiangdong XuDepartment of Pathology, University of California, San Diego, La Jolla, California, USA.
Gene W YeoDepartment of Cellular and Molecular Medicine, Institute for Genomic Medicine, UCSD Stem Cell Program, University of California, San Diego, La Jolla, California, USA.
James Bradley AimoneCenter for Computing Research, Sandia National Laboratories, Albuquerque, New Mexico, USA.
Fred H GageLaboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California, USA. Electronic address: gage@salk.edu.
Salk Institute for Biological Studies · USUniversity of California San Diego · USChildren’s Institute · USIstanbul Medipol University · TRSandia National Laboratories · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disorders that disrupt myelin formation during development or in adulthood, such as multiple sclerosis and peripheral neuropathies, lead to severe pathologies, illustrating myelin's crucial role in normal neural functioning. However, although our understanding of glial biology is increasing, the signals that emanate from axons and regulate myelination remain largely unknown. To identify the core components of the myelination process, here we adopted a microarray analysis approach combined with laser-capture microdissection of spinal motoneurons during the myelinogenic phase of development. We identified neuronal genes whose expression was enriched during myelination and further investigated hepatoma-derived growth factor-related protein 3 (HRP3 or HDGFRP3). HRP3 was strongly expressed in the white matter fiber tracts of the peripheral (PNS) and central (CNS) nervous systems during myelination and remyelination in a cuprizone-induced demyelination model. The dynamic localization of HPR3 between axons and nuclei during myelination was consistent with its axonal localization during neuritogenesis. To study this phenomenon, we identified two splice variants encoded by the

Indexed as

Gene Expression ProfilingAnimalsAxonsCell NucleusCoculture TechniquesCuprizoneDemyelinating DiseasesIntracellular Signaling Peptides and ProteinsMaleMiceMotor NeuronsMyelin SheathNeurogliaProtein IsoformsRatsCuprizoneHdgfl3 protein, mouseIntracellular Signaling Peptides and ProteinsProtein Isoformsalternative splicingaxonHDGFRP3hepatoma-derived growth factor-related protein 3 (HRP3)myelinneuritogenesisnuclear translocationoligodendrocyteSchwann cellsspinal motoneuron

Identifiers

PMID32647008
PMCPMC7443494
OpenAlexW3041657182

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.