ArticleCancer research2020
Epigenetic CRISPR Screens Identify
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Article in Cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 29 citations in OpenAlex.
- DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling-Mediated Anti-tumor Immunity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Stearoyl-CoA Desaturase-1 Drives Tumor Growth by Interacting With Histone Deacetylase-2 and Deacetylating Nucleophosmin-1.MedComm · 2026Article
- Article
- NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Nucleophosmin supports WNT-driven hyperproliferation and tumor initiation.Nature genetics · 2026Article
- A novel mouse cell line model reveals the tumor intrinsic and immune characteristics of EGFR-mutant lung cancer.Theranostics · 2026Article
- SERPINB3 enhances NPM1 sumoylation via inhibiting SENP3's activity and promotes lung tumorigenesis.Cell death & disease · 2025Article
- Epigenetic reprogramming as the nexus of cancer stemness and therapy resistance: implications for biomarker discovery.Discover oncology · 2025Review
- Mechanism of Action of Resveratrol Affecting the Biological Function of Breast Cancer Through the Glycolytic Pathway.World journal of oncology · 2025Article
- Integrative multi-omics identifies AP-1 transcription factor as a targetable mediator of acquired osimertinib resistance in non-small cell lung cancer.Cell death & disease · 2025Article
- Predictive value of dendritic cell-related genes for prognosis and immunotherapy response in lung adenocarcinoma.Cancer cell international · 2025Article
- NPM1 inhibits tumoral antigen presentation to promote immune evasion and tumor progression.Journal of hematology & oncology · 2024Article
- CRISPRingCancers · 2024Review
- RNA splicing alterations in lung cancer pathogenesis and therapy.Cancer pathogenesis and therapy · 2023Review
- Nucleophosmin Plays a Role in Repairing DNA Damage and Is a Target for Cancer Treatment.Cancer research · 2023Review
- Profiling of phosphorylated metabolites from lung cancer by zeolite loaded Mg-Al-Ce ternary hydroxide (Zeolite@MAC) composite.Heliyon · 2023Article
- A "grappling hook" interaction connects self-assembly and chaperone activity of Nucleophosmin 1.PNAS nexus · 2023Article
- Synthetic Vulnerabilities in the KRAS Pathway.Cancers · 2022Review
- Current applications and future perspective of CRISPR/Cas9 gene editing in cancer.Molecular cancer · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors at 7 institutions in 3 countries.
Fei Li *Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, New York.
Wai-Lung Ng *Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.ORCID 0000-0003-2892-6318
Troy A LusterBelfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts.ORCID 0000-0002-7396-0171
Hai HuLaura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, New York.
Vladislav O SviderskiyDepartment of Pathology, New York University School of Medicine, New York, New York.
Catríona M DowlingLaura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, New York.ORCID 0000-0001-7887-9332
Kate E R HollinsheadDepartment of Radiation Oncology, Perlmutter Cancer Center, New York University School of Medicine, New York, New York.
Paula ZouitineDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Hua ZhangLaura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, New York.
Qingyuan HuangLaura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, New York.
Michela RanieriLaura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, New York.
Wei WangS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Zhaoyuan FangState Key Laboratory of Cell Biology, Innovation Center for Cell Signaling Network, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Ting ChenLaura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, New York.ORCID 0000-0003-1725-7956
Jiehui DengLaura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, New York.
Kai ZhaoSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Sha Tin, Hong Kong SAR, China.
Hon-Cheong SoSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Sha Tin, Hong Kong SAR, China.
Alireza Khodadadi-JamayranApplied Bioinformatics Laboratories and Genome Technology Center, Division of Advanced Research Technologies, New York University Grossman School of Medicine, NYU Langone Health, New York, New York.ORCID 0000-0003-2495-7504
Mousheng XuDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Angeliki KaratzaLaura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, New York.
Val PyonLaura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, New York.
Shuai LiLaura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, New York.
Yuanwang PanLaura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, New York.
Kristen LabbeLaura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, New York.
Christina AlmonteLaura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, New York.
John T PoirierLaura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, New York.ORCID 0000-0001-9795-5644
George MillerS. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, New York, New York.
Richard PossematoDepartment of Pathology, New York University School of Medicine, New York, New York.ORCID 0000-0002-2401-0030
Jun QiDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts. Kwok-Kin.Wong@nyulangone.org Jun_Qi@dfci.harvard.edu.ORCID 0000-0002-1461-3356
Kwok-Kin WongLaura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, New York. Kwok-Kin.Wong@nyulangone.org Jun_Qi@dfci.harvard.edu.
NYU Langone Health · USNew York University · USHarvard University · USChinese University of Hong Kong · HKDana-Farber Cancer Institute · USCenter for Excellence in Molecular Cell Science · CNNew York Genome Center · US
Funding
StructureP01CA154303 · NCI · DANA-FARBER CANCER INST · PI JANNE, PASI A · 2012 to 2021
$17.8MTherapeutic approaches for LKB1-deficient non-small cell lung cancerR01CA205150 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI HEYMACH, JOHN V., WONG, KWOK KIN · 2016 to 2020
$3.0MEZH2 in cancer biology and novel inhibitorsR01CA222218 · NCI · DANA-FARBER CANCER INST · PI QI, JUN · 2018 to 2022
$2.6MTargeting Metabolic Liabilities in CancerR01CA214948 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI POSSEMATO, RICHARD LEWIS · 2018 to 2022
$1.9MRegulation Of Metabolism And Gene Expression By Iron-Sulfur Clusters - SupplementR01GM132491 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI POSSEMATO, RICHARD LEWIS · 2020 to 2023
$1.9MNCI NIH HHS P01 CA154303NCI NIH HHS R01 CA205150NCI NIH HHS R01 CA214948NCI NIH HHS R01 CA222218NIGMS NIH HHS R01 GM132491
Abstract
Despite advancements in treatment options, the overall cure and survival rates for non-small cell lung cancers (NSCLC) remain low. While small-molecule inhibitors of epigenetic regulators have recently emerged as promising cancer therapeutics, their application in patients with NSCLC is limited. To exploit epigenetic regulators as novel therapeutic targets in NSCLC, we performed pooled epigenome-wide CRISPR knockout screens
Indexed as
Carcinoma, Non-Small-Cell LungGenetic TechniquesLung NeoplasmsAnimalsCell Line, TumorClustered Regularly Interspaced Short Palindromic RepeatsEpigenesis, GeneticHeterograftsHumansMiceNuclear ProteinsNucleophosminNPM1 protein, humanNpm1 protein, mouseNuclear ProteinsNucleophosmin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.