Evidence map›Paper›PMID 32646947›Full record

ArticleAJNR. American journal of neuroradiology2020

Association of Isolated Congenital Heart Disease with Fetal Brain Maturation.

C Jaimes, V Rofeberg, C Stopp, C M Ortinau, A Gholipour, K G Friedman, W Tworetzky, J Estroff, J W Newburger, D Wypij and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Article
  3. Cord blood levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 correlate with perinatal brain development in fetal congenital heart disease.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025
    Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Fetal Brain Development in Congenital Heart Disease.The Canadian journal of cardiology · 2023
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

C JaimesFrom the Departments of Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Cardiology (V.R., C.S., K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Fetal-Neonatal Neuroimaging and Developmental Science Center (C.J.), Boston Children's Hospital, Boston, Massachusetts.ORCID 0000-0002-7169-4244
V RofebergFrom the Departments of Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Cardiology (V.R., C.S., K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Fetal-Neonatal Neuroimaging and Developmental Science Center (C.J.), Boston Children's Hospital, Boston, Massachusetts.ORCID 0000-0002-0053-1536
C StoppFrom the Departments of Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Cardiology (V.R., C.S., K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Fetal-Neonatal Neuroimaging and Developmental Science Center (C.J.), Boston Children's Hospital, Boston, Massachusetts.ORCID 0000-0002-6360-5993
C M OrtinauPediatrics (C.M.O.), Washington University in St. Louis, St. Louis, Missouri.ORCID 0000-0003-0851-0796
A GholipourFrom the Departments of Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Cardiology (V.R., C.S., K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Fetal-Neonatal Neuroimaging and Developmental Science Center (C.J.), Boston Children's Hospital, Boston, Massachusetts.ORCID 0000-0001-7699-4564
K G FriedmanFrom the Departments of Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Cardiology (V.R., C.S., K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Fetal-Neonatal Neuroimaging and Developmental Science Center (C.J.), Boston Children's Hospital, Boston, Massachusetts.ORCID 0000-0002-3180-9764
W TworetzkyFrom the Departments of Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Cardiology (V.R., C.S., K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Fetal-Neonatal Neuroimaging and Developmental Science Center (C.J.), Boston Children's Hospital, Boston, Massachusetts.ORCID 0000-0002-8422-2158
J EstroffFrom the Departments of Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Cardiology (V.R., C.S., K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Fetal-Neonatal Neuroimaging and Developmental Science Center (C.J.), Boston Children's Hospital, Boston, Massachusetts.ORCID 0000-0002-4578-2531
J W NewburgerFrom the Departments of Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Cardiology (V.R., C.S., K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Fetal-Neonatal Neuroimaging and Developmental Science Center (C.J.), Boston Children's Hospital, Boston, Massachusetts.ORCID 0000-0002-7794-9017
D WypijFrom the Departments of Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Cardiology (V.R., C.S., K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Fetal-Neonatal Neuroimaging and Developmental Science Center (C.J.), Boston Children's Hospital, Boston, Massachusetts.ORCID 0000-0001-8367-8711
S K WarfieldFrom the Departments of Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Cardiology (V.R., C.S., K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Fetal-Neonatal Neuroimaging and Developmental Science Center (C.J.), Boston Children's Hospital, Boston, Massachusetts.ORCID 0000-0002-7659-3880
E YangFrom the Departments of Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Cardiology (V.R., C.S., K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Fetal-Neonatal Neuroimaging and Developmental Science Center (C.J.), Boston Children's Hospital, Boston, Massachusetts.ORCID 0000-0002-9912-4163
C K RollinsFrom the Departments of Radiology (C.J., A.G., J.E., S.K.W., E.Y.), Cardiology (V.R., C.S., K.G.F., W.T., J.W.N., D.W.), Neurology (C.K.R.), Fetal-Neonatal Neuroimaging and Developmental Science Center (C.J.), Boston Children's Hospital, Boston, Massachusetts caitlin.rollins@childrens.harvard.edu.ORCID 0000-0002-0500-0056
Boston Children's Hospital · USWashington University in St. Louis · US

Funding

Advancing Microstructural and Vascular Neuroimaging in Perinatal StrokeR01NS106030 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI WARFIELD, SIMON K · 2019 to 2023
$1.7M
Motion-robust super-resolution diffusion weighted MRI of early brain developmentR01EB018988 · NIBIB · BOSTON CHILDREN'S HOSPITAL · PI GHOLIPOUR-BABOLI, ALI · 2014 to 2017
$1.6M
Improved Quantitative Assessment of the Fetal Brain from 3D Volumetric MRIR01EB013248 · NIBIB · BOSTON CHILDREN'S HOSPITAL · PI WARFIELD, SIMON K · 2012 to 2015
$1.5M
Fetal Brain Development in Congenital Heart DiseaseK23NS101120 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI ROLLINS, CAITLIN · 2017 to 2022
$1.1M
Physiologic and Genetic Contributions of Impaired Fetal Brain Development in Congenital Heart DiseaseK23HL141602 · NHLBI · WASHINGTON UNIVERSITY · PI ORTINAU, CYNTHIA MARIE · 2019 to 2022
$727k
NHLBI NIH HHS K23 HL141602NIBIB NIH HHS R01 EB013248NIBIB NIH HHS R01 EB018988NINDS NIH HHS K23 NS101120NINDS NIH HHS R01 NS106030
6 · The paper itself

Abstract

background and purposeBrain MRI of newborns with congenital heart disease show signs of immaturity relative to healthy controls. Our aim was to determine whether the semiquantitative fetal total maturation score can detect abnormalities in brain maturation in fetuses with congenital heart disease in the second and third trimesters. MATERIALS AND

methodsWe analyzed data from a prospective study of fetuses with and without congenital heart disease who underwent fetal MR imaging at 25-35 weeks' gestation. Two independent neuroradiologists blinded to the clinical data reviewed and scored all images using the fetal total maturation score. Interrater reliability was evaluated by the intraclass correlation coefficient using the individual reader scores, which were also used to calculate an average score for each subject. Comparisons of the average and individual reader scores between affected and control fetuses and relationships with clinical variables were evaluated using multivariable linear regression.

resultsData from 69 subjects (48 cardiac, 21 controls) were included. High concordance was observed between readers with an intraclass correlation coefficient of 0.98 (95% CI, 0.97-0.99). The affected group had significantly lower fetal total maturation scores than the control group (

conclusionsThe fetal total maturation score is sensitive to differences in brain maturation between fetuses with isolated congenital heart disease and healthy controls.

Indexed as

AdultBrainFemaleFetusHeart Defects, CongenitalHumansImage Interpretation, Computer-AssistedInfant, NewbornMagnetic Resonance ImagingMalePregnancyPrenatal DiagnosisProspective StudiesReproducibility of Results

Identifiers

PMID32646947
PMCPMC7658885
OpenAlexW3041583564

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.