SynthesisAJNR. American journal of neuroradiology2020
The Risk of Stroke and TIA in Nonstenotic Carotid Plaques: A Systematic Review and Meta-Analysis.
Synthesis in AJNR. American journal of neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Association Between Ipsilateral Stroke and Nonstenotic (<50%) Carotid Disease: Secondary Analysis From the AcT Trial.Journal of the American Heart Association · 2026Trial
- Symptomatic Non-stenotic Carotid Disease in Embolic Stroke of Undetermined Source : Analysis of the ESCAPE-NA1 Trial.Clinical neuroradiology · 2024Trial
- Eco-Friendly In-Situ Zwitterionization of Stent Metals with Phosphonic Sulfobetaine Copolymers for Durable Antibiofouling and Hemocompatibility.Langmuir : the ACS journal of surfaces and colloids · 2026Article
- Covert macrovascular disease and early outcome after ischemic cerebrovascular events.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Observational
- Non-stenotic Carotid Disease: Review of the Literature and Case Discussion of TCAR for Treatment.Seminars in neurology · 2026Review
- Impact of Proton Pump Inhibitor Use on Outcomes Following Carotid Artery Stenting for Asymptomatic Carotid Stenosis: A Population-Based Cohort Study.The Kaohsiung journal of medical sciences · 2026Article
- Development and interpretation of a dual-energy CT-based deep learning radiomics model for predicting new cerebral ischemic lesions after carotid artery stenting: a multicenter study.European radiology · 2026Article
- Associations between phenotypic age and carotid atherosclerosis among the general population: evidence from a multi-stage study.BMC cardiovascular disorders · 2026Article
- Article
- Proteomic machine-learning signatures associated with carotid plaque: A population-based hypothesis-generating study.PloS one · 2026Article
- Real-World Smartphone Data Predicts Mood After Ischemic Stroke and Transient Ischemic Attack Symptoms and May Constitute Digital Endpoints: A Proof-of-Concept Study.Mayo Clinic proceedings. Digital health · 2025Article
- Use of optical coherence tomography in selected patients with recurrent cryptogenic stroke: A case series and technical discussion.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Symptomatic Cervical Carotid Artery Stenosis: Evolving Paradigms in Risk Stratification and Intervention.Annals of Indian Academy of Neurology · 2025Article
- The role of intraplaque neovascularization in recent and future ischemic stroke in patients with mild carotid stenosis.Ultrasonography (Seoul, Korea) · 2025Article
- The role of non-stenosing carotid artery plaques in embolic stroke of undetermined source, is it a silent offender? A review of literature.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024Review
- Investigating the Added Value of Beck's Depression Inventory in Atherosclerosis Prediction: Lessons from Paracelsus 10,000.Journal of clinical medicine · 2024Article
- The Attributable Risk of Nonstenotic Cervical Carotid Plaque in Cryptogenic Embolic Stroke.Stroke (Hoboken, N.J.) · 2023Review
- QSM Throughout the Body.Journal of magnetic resonance imaging : JMRI · 2023Review
- Low-grade carotid artery stenosis is associated with progression of brain atrophy and cognitive decline. The SMART-MR study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Sleep apnea-COPD overlap syndrome is associated with larger left carotid atherosclerotic plaques.Frontiers in cardiovascular medicine · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSevere carotid stenosis carries a high risk of stroke. However, the risk of stroke with nonstenotic carotid plaques (<50%) is increasingly recognized. PURPOSE: We aimed to summarize the risk of TIA or stroke in patients with nonstenotic carotid plaques. DATA SOURCES: We performed a comprehensive systematic review and meta-analysis in patients with acute ischemic stroke in whom carotid imaging was performed using MEDLINE and the Cochrane Database, including studies published up to December 2019. STUDY SELECTION: Included studies had >10 patients with <50% carotid plaques on any imaging technique and reported the incidence or recurrence of ischemic stroke/TIA. High-risk plaque features and the risk of progression to stenosis >50% were extracted if reported. DATA SYNTHESIS: We identified 31 studies reporting on the risk of ipsilateral stroke/TIA in patients with nonstenotic carotid plaques. Twenty-five studies ( DATA ANALYSIS: The incidence of first-ever ipsilateral stroke/TIA was 0.5/100 person-years. The risk of recurrent stroke/TIA was 2.6/100 person-years and increased to 4.9/100 person-years if intraplaque hemorrhage was present. The risk of progression to severe stenosis (>50%) was 2.9/100 person-years (8 studies, LIMITATIONS: Included studies showed heterogeneity in reporting stroke etiology, the extent of stroke work-up, imaging modalities, and classification systems used for characterizing carotid stenosis.
conclusionsThe risk of recurrent stroke/TIA in nonstenotic carotid plaques is not negligible, especially in the presence of high-risk plaque features. Further research is needed to better define the significance of nonstenotic carotid plaques for stroke etiology.
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