Evidence map›Paper›PMID 32646877›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2021

Immune-Checkpoint Blockade Enhances

Johannes Czernin, Kyle Current, Christine E Mona, Lea Nyiranshuti, Firas Hikmat, Caius G Radu, Katharina Lückerath

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Combination therapy of anEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
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  9. Review
  10. Development of aCellular oncology (Dordrecht, Netherlands) · 2025
    Article
  11. Article
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  15. A new era of cancer immunotherapy: vaccines and miRNAs.Cancer immunology, immunotherapy : CII · 2025
    Review
  16. Article
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  18. Evaluating [European journal of nuclear medicine and molecular imaging · 2024
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Johannes CzerninDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California.
Kyle CurrentDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California.
Christine E MonaDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California.
Lea NyiranshutiDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California.
Firas HikmatDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California.
Caius G RaduDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California.
Katharina LückerathDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California klueckerath@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

Transductionally Redirected /Transcriptionally RestricteP50CA086306 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HERSCHMAN, HARVEY R. · 2000 to 2014
$29.0M
PET Imaging-guided Personalized Therapy in Pancreatic CancerR01CA187678 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CZERNIN, JOHANNES, DONAHUE, TIMOTHY R · 2014 to 2018
$2.8M
NCI NIH HHS P50 CA086306NCI NIH HHS R01 CA187678
6 · The paper itself

Abstract

Prostate-specific membrane antigen (PSMA)-targeted radionuclide therapy (RNT) may increase tumor immunogenicity. We aimed at exploiting this effect by combining RNT with immunotherapy in a mouse model of prostate cancer (PC).

Indexed as

ActiniumAnimalsCell Line, TumorDipeptidesDisease Models, AnimalHeterocyclic Compounds, 1-RingHumansImmune Checkpoint InhibitorsImmunotherapyMaleMiceMice, Inbred C57BLProgrammed Cell Death 1 ReceptorProstate-Specific AntigenProstatic Neoplasms(225)Ac-PSMA-617ActiniumDipeptidesHeterocyclic Compounds, 1-RingImmune Checkpoint InhibitorsProgrammed Cell Death 1 ReceptorProstate-Specific Antigen225Ac-PSMAimmunotherapyPD-1prostate cancersyngeneic mouse model

Identifiers

PMID32646877
PMCPMC12079179
OpenAlexW3041016676

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.