ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2020
Holder pasteurization of donated human milk is effective in inactivating SARS-CoV-2.
Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Virucidal Efficacy of Holder Pasteurization of Breast Milk in a Portable Device.Pathogens (Basel, Switzerland) · 2026Article
- COVID-19 detection in bone tissue after a new protocol for decellularize bone with sustained collagen matrix.Cell and tissue banking · 2025Article
- The global status of human milk banking.Maternal & child nutrition · 2024Review
- Review of current best practices for human milk banking.Maternal & child nutrition · 2024Review
- Viruses and Human Milk: Transmission or Protection?Advances in nutrition (Bethesda, Md.) · 2023Review
- Article
- Review
- General approach to delivery and resuscitation of newborn infants from mothers at risk or proven COVID-19.Seminars in fetal & neonatal medicine · 2023Review
- COVID-19 Disease in Under-5 Children: Current Status and Strategies for Prevention including Vaccination.Vaccines · 2023Review
- [Perinatal and neonatal management plan for prevention and control of SARS-CoV-2 infection (3rd Edition)].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023Article
- Breastfeeding during the COVID-19 pandemic.Frontiers in pediatrics · 2023Review
- Disinfection and decontamination in the context of SARS-CoV-2-specific data.Journal of medical virology · 2022Review
- Guidance for the clinical management of infants born to mothers with suspected/confirmed COVID-19 in Singapore.Singapore medical journal · 2022Review
- Identified human breast milk compositions effectively inhibit SARS-CoV-2 and variants infection and replication.iScience · 2022Article
- Recommendations for breastfeeding during Coronavirus Disease 2019 (COVID-19) pandemic.International breastfeeding journal · 2022Review
- SARS-CoV-2 Remains Infectious on Refrigerated Deli Food, Meats, and Fresh Produce for up to 21 Days.Foods (Basel, Switzerland) · 2022Article
- Overview of Breastfeeding Under COVID-19 Pandemic.Frontiers in immunology · 2022Review
- Preservation of Anti-cytomegalovirus Activity in Human Milk Following High-Pressure Processing Compared to Holder Pasteurization.Frontiers in nutrition · 2022Article
- Neonates and COVID-19: state of the art : Neonatal Sepsis series.Pediatric research · 2022Review
- The impact of the Covid-19 pandemic on North American milk banks.Maternal & child nutrition · 2021Article
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7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProvision of pasteurized donor human milk, as a bridge to mother's own milk, is the standard of care for very low-birth-weight infants in hospital. The aim of this research was to confirm that Holder pasteurization (62.5°C for 30 min) would be sufficient to inactivate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in donated human milk samples.
methodsWe spiked frozen milk samples from 10 donors to the Rogers Hixon Ontario Human Milk Bank with SARS-CoV-2 to achieve a final concentration of 1 × 10
resultsWe detected no cytopathic activity in any of the SARS-CoV-2-spiked milk samples that had been pasteurized using the Holder method. In the SARS-CoV-2-spiked milk samples that were not pasteurized but were kept at room temperature for 30 minutes, we observed a reduction in infectious viral titre of about 1 log.
interpretationPasteurization of human milk by the Holder method (62.5°C for 30 min) inactivates SARS-CoV-2. Thus, in the event that donated human milk contains SARS-CoV-2 by transmission through the mammary gland or by contamination, this method of pasteurization renders milk safe for consumption and handling by care providers.
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