Evidence map›Paper›PMID 32646856›Full record

ArticleJournal of the American Society of Nephrology : JASN2020

Lipocalin-2 Exacerbates Lupus Nephritis by Promoting Th1 Cell Differentiation.

Weiwei Chen, Wenchao Li, Zhuoya Zhang, Xiaojun Tang, Shufang Wu, Genhong Yao, Kang Li, Dandan Wang, Yuemei Xu, Ruihai Feng and 6 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05539001 (Screening Biomarkers for Severe Lupus Based on Multi-omics Studies), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05539001 unknown statusnot on this mapstarted 2023, after this paper: background citation

Screening Biomarkers for Severe Lupus Based on Multi-omics Studies

Typeobservational_patient_registrySponsorThe Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical SchoolRan2023 to 2025Enrolled152ConditionsSystemic Lupus Erythematosus
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.

  1. Pooled it
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  20. Spatial proteomics landscape and immune signature analysis of renal sample of lupus nephritis based on laser-captured microsection.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Weiwei ChenDepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Model Animal Research Center of Nanjing University, Nanjing, China.ORCID 0000-0001-8616-1419
Wenchao LiDepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Model Animal Research Center of Nanjing University, Nanjing, China licj@nju.edu.cn lingyunsun@nju.edu.cn.
Zhuoya ZhangDepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Model Animal Research Center of Nanjing University, Nanjing, China.
Xiaojun TangDepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Model Animal Research Center of Nanjing University, Nanjing, China.
Shufang WuDepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Model Animal Research Center of Nanjing University, Nanjing, China.
Genhong YaoDepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Model Animal Research Center of Nanjing University, Nanjing, China.
Kang LiDepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Model Animal Research Center of Nanjing University, Nanjing, China licj@nju.edu.cn lingyunsun@nju.edu.cn.
Dandan WangDepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Model Animal Research Center of Nanjing University, Nanjing, China.
Yuemei XuDepartment of Pathology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Ruihai FengDepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Model Animal Research Center of Nanjing University, Nanjing, China.
Xiaoxiao DuanDepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Model Animal Research Center of Nanjing University, Nanjing, China.
Xiangshan FanDepartment of Pathology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Liwei LuDepartment of Pathology, Center of Infection and Immunology, University of Hong Kong, Hong Kong, China.
WanJun ChenMucosal Immunology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland.
Chaojun LiDepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Model Animal Research Center of Nanjing University, Nanjing, China licj@nju.edu.cn lingyunsun@nju.edu.cn.ORCID 0000-0001-9474-7321
Lingyun SunDepartment of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Model Animal Research Center of Nanjing University, Nanjing, China licj@nju.edu.cn lingyunsun@nju.edu.cn.
Model Animal Research Center · CNChina Pharmaceutical University · CNNanjing Drum Tower Hospital · CNNational Institutes of Health · USUniversity of Hong Kong · HK

Funding

TGF-beta Regulation of Mucosal and Systemic T Cell Immunity and ToleranceZIADE000101 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI CHEN, WANJUN · 2009 to 2025
$36.9M
6 · The paper itself

Abstract

backgroundLipocalin-2 (LCN2) is an indicator of the severity of lupus nephritis (LN) and plays a pivotal role in immune responses, but it is not known if its effect on LN pathogenesis derives from regulating the immune imbalance of T lymphocyte subsets.

methodsThe expression of LCN2 in T cells and kidneys was assessed in renal biopsies from patients with LN. We investigated the relationship between LCN2 levels and development of LN and systemic illness by injecting anti-LCN2 antibodies into MRL/

resultsLCN2 is highly expressed in CD4

conclusionsLCN2 plays a crucial role in Th1 cell differentiation, and may present a potential therapeutic target for LN.

Indexed as

AnimalsCase-Control StudiesCell DifferentiationDisease Models, AnimalFemaleHumansLipocalin-2Lupus NephritisMaleMiceMice, Inbred MRL lprTh1 CellsLipocalin-2lipocalin-2lupus nephritisTh1 cells

Identifiers

PMID32646856
PMCPMC7609012
OpenAlexW3042180132

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.