Evidence map›Paper›PMID 32646715›Full record

ArticleMedical dosimetry : official journal of the American Association of Medical Dosimetrists

Comparison of conventional and advanced radiotherapy techniques for left-sided breast cancer after breast conserving surgery.

Yibo Xie, Daniel Bourgeois, Beibei Guo, Rui Zhang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical dosimetry : official journal of the American Association of Medical Dosimetrists. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Yibo XieDepartment of Physics and Astronomy, Louisiana State University, Baton Rouge, LA, USA.
Daniel BourgeoisDepartment of Radiation Oncology, Mary Bird Perkins Cancer Center, Baton Rouge, LA, USA.
Beibei GuoDepartment of Experimental Statistics, Louisiana State University, Baton Rouge, LA, USA.
Rui ZhangDepartment of Physics and Astronomy, Louisiana State University, Baton Rouge, LA, USA; Department of Radiation Oncology, Mary Bird Perkins Cancer Center, Baton Rouge, LA, USA. Electronic address: rzhang@lsu.edu.
Louisiana State University · USMary Bird Perkins Cancer Center · US

Funding

Systematic evaluation of predicted outcomes and costs to inform clinical and policy decision making for emerging postmastectomy radiotherapiesK22CA204464 · NCI · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI ZHANG, RUI · 2016 to 2018
$580k
NCI NIH HHS K22 CA204464
6 · The paper itself

Abstract

Whole breast radiotherapy (WBRT) after breast conserving surgery is the standard treatment to prevent recurrence and metastasis of early stage breast cancer. This study aims to compare seven WBRT techniques including conventional tangential, field-in-field (FIF), hybrid intensity-modulated radiotherapy (IMRT), IMRT, standard volumetric modulated arc therapy (STD-VMAT), noncoplanar VMAT (NC-VMAT), and multiple arc VMAT (MA-VMAT). Fifteen patients who were previously diagnosed with left-sided early stage breast cancer and treated in our clinic were selected for this study. WBRT plans were created for these patients and were evaluated based on target coverage and normal tissue toxicities. All techniques produced clinically acceptable WBRT plans. STD-VMAT delivered the lowest mean dose (1.1 ± 0.3 Gy) and the lowest maximum dose (7.3 ± 4.9 Gy) to contralateral breast, and the second lowest lifetime attributable risk (LAR) (4.1 ± 1.4%) of secondary contralateral breast cancer. MA-VMAT delivered the lowest mean dose to lungs (4.9 ± 0.9 Gy) and heart (5.5 ± 1.2 Gy), exhibited the lowest LAR (1.7 ± 0.3%) of secondary lung cancer, normal tissue complication probability (NTCP) (1.2 ± 0.2%) of pneumonitis, risk of coronary events (RCE) (10.3 ± 2.7%), and LAR (3.9 ± 1.3%) of secondary contralateral breast cancer. NC-VMAT plans provided the most conformal target coverage, the lowest maximum lung dose (46.2 ± 4.1 Gy) and heart dose (41.1 ± 5.4 Gy), and the second lowest LAR (1.8 ± 0.4%) of secondary lung cancer and RCE (10.5 ± 2.8%). MA-VMAT and NC-VMAT could be the preferred techniques for early stage breast cancer patients after breast conserving surgery.

Indexed as

Breast NeoplasmsRadiotherapy, Intensity-ModulatedUnilateral Breast NeoplasmsFemaleHumansMastectomy, SegmentalRadiotherapy DosageRadiotherapy Planning, Computer-AssistedConventional tangentialField-in-FieldIntensity-modulated radiotherapyLumpectomyVolumetric modulated arc therapyWhole breast radiotherapy

Identifiers

PMID32646715
PMCPMC7609481
OpenAlexW3041197994

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.