SynthesisMedicina intensiva
[Systematic review of the prognostic utility of D-dimer, disseminated intravascular coagulation, and anticoagulant therapy in COVID-19 critically ill patients].
Synthesis in Medicina intensiva. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05102708 (Study of COVID-19 Prognostic Factors in Hospitalized Patients), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study of COVID-19 Prognostic Factors in Hospitalized Patients
Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Pulmonary Embolism in COVID-19: Trends from a Single-Center Study Across Ten Pandemic Waves in Romania.Microorganisms · 2025Article
- Innovation through Artificial Intelligence in Triage Systems for Resource Optimization in Future Pandemics.Biomimetics (Basel, Switzerland) · 2024Article
- Coagulation and Inflammation in COVID-19: Reciprocal Relationship between Inflammatory and Coagulation Markers.Annals of hematology · 2024Review
- The value of immature granulocyte percentage united with D-Dimer in the evaluation of severe pancreatitis and its prognosis.Clinics (Sao Paulo, Brazil) · 2024Article
- [Critical patients COVID-19 has changed the management and outcomes in the ICU after 1 year of the pandemic? A multicenter, prospective, observational study].Enfermedades infecciosas y microbiologia clinica · 2023Article
- Critical patients COVID-19 has changed the management and outcomes in the ICU after 1 year of the pandemic? A multicenter, prospective, observational study.Enfermedades infecciosas y microbiologia clinica (English ed.) · 2023Observational
- Testosterone as a Biomarker of Adverse Clinical Outcomes in SARS-CoV-2 Pneumonia.Biomedicines · 2022Article
- Predicting respiratory failure in patients infected by SARS-CoV-2 by admission sex-specific biomarkers.Biology of sex differences · 2021Article
- Current systematic reviews and meta-analyses of COVID-19.World journal of virology · 2021Article
- Classification and analysis of outcome predictors in non-critically ill COVID-19 patients.Internal medicine journal · 2021Article
- Use and misuse of biomarkers and the role of D-dimer and C-reactive protein in the management of COVID-19: A post-hoc analysis of a prospective cohort study.Clinics (Sao Paulo, Brazil) · 2021Article
- Hypercoagulopathy in Severe COVID-19: Implications for Acute Care.Thrombosis and haemostasis · 2020Review
- Rickettsia rickettsii and Rickettsia typhi in hospitalized children diagnosed with Pediatric Multisystemic Inflammatory Syndrome in Merida, Yucatan.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the new pandemic caused by SARS-CoV-2, there is short knowledge regarding the management of different disease areas, such as coagulopathy and interpretation of D-dimer levels, its association with disseminated intravascular coagulation (DIC) and controversy about the benefit of anticoagulation. Thus, a systematic review has been performed to define the role of D-dimer in the disease, the prevalence of DIC and the usefulness of anticoagulant treatment in these patients. A literature search was performed to analyze the studies of COVID-19 patients. Four recommendations were drawn based on expert opinion and scientific knowledge, according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. The present review suggests the presence of higher levels of D-dimer in those with worse prognosis, there may be an overdiagnosis of DIC in the course of the disease and there is no evidence on the benefit of starting anticoagulant treatment based only on isolated laboratory data.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.