Evidence map›Paper›PMID 32646579›Full record

ReviewTrends in cell biology2020

Polyploidy: A Biological Force From Cells to Ecosystems.

Donald T Fox, Douglas E Soltis, Pamela S Soltis, Tia-Lynn Ashman, Yves Van de Peer

Open access · bronzeAbstract readReview
In one paragraph

Review in Trends in cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
128citing papers in PubMed, 1 pooled it
32.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

128 citing papers in PubMed, 1 synthesis or guideline pooled it, 235 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Polyploidy: A macromutational force pushing bioeconomic developments.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Review
  8. Growth under pressure: The pros and cons of polyploidy induced by stress.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Cell Fusion in Reprogramming and Regeneration.Advances in experimental medicine and biology · 2026
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review

68 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 4 countries.

Donald T FoxDepartment of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA. Electronic address: don.fox@duke.edu.
Douglas E SoltisFlorida Museum of Natural History, University of Florida, Gainesville, FL 32611, USA; Department of Biology, University of Florida, Gainesville, FL 32611, USA. Electronic address: dsoltis@ufl.edu.
Pamela S SoltisFlorida Museum of Natural History, University of Florida, Gainesville, FL 32611, USA. Electronic address: psoltis@flmnh.ufl.edu.
Tia-Lynn AshmanDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address: tia1@pitt.edu.
Yves Van de PeerDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium; VIB Center for Plant Systems Biology, Ghent, Belgium; Department of Biochemistry, Genetics and Microbiology, University of Pretoria, Pretoria, South Africa; College of Horticulture, Nanjing Agricultural University, Nanjing, China. Electronic address: yves.vandepeer@psb.vib-ugent.be.
Florida Museum of Natural History · USDuke University · USNanjing Agricultural University · CNUniversity of Pittsburgh · US

Funding

Polyploidy after tissue injury: a Drosophila modelR01GM118447 · NIGMS · DUKE UNIVERSITY · PI FOX, DONALD T. · 2016 to 2025
$3.1M
NIGMS NIH HHS R01 GM118447
6 · The paper itself

Abstract

Polyploidy, resulting from the duplication of the entire genome of an organism or cell, greatly affects genes and genomes, cells and tissues, organisms, and even entire ecosystems. Despite the wide-reaching importance of polyploidy, communication across disciplinary boundaries to identify common themes at different scales has been almost nonexistent. However, a critical need remains to understand commonalities that derive from shared polyploid cellular processes across organismal diversity, levels of biological organization, and fields of inquiry - from biodiversity and biocomplexity to medicine and agriculture. Here, we review the current understanding of polyploidy at the organismal and suborganismal levels, identify shared research themes and elements, and propose new directions to integrate research on polyploidy toward confronting interdisciplinary grand challenges of the 21

Indexed as

EcosystemPolyploidyGenomeStress, Physiologicalcellular polyploidyendoreplicationorganismal polyploidypolyploidywhole-genome duplication

Identifiers

PMID32646579
PMCPMC7484144
OpenAlexW3039000556

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.