ReviewCurrent problems in cardiology2021
Role of Periodontal Infection, Inflammation and Immunity in Atherosclerosis.
Review in Current problems in cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Association between periodontitis and subclinical vascular dysfunction: a systematic review and meta-analysis.Odontology · 2026Review
- Association ofJournal of clinical medicine · 2026Review
- Article
- The Association of Periodontitis With Cardiovascular Disease Parameters: A Synthesis of Systematic Reviews.International journal of dental hygiene · 2026Review
- 16S rRNA analysis of proximal dental plaque bacteria reveals that daily use of commercialized disposable dental floss ItoyojiBMC oral health · 2026Article
- Assessment of the association between coronary artery blockage and periodontal health status in patients undergoing coronary angiography: a cross-sectional study.Medicina oral, patologia oral y cirugia bucal · 2025Article
- Metagenomic Insights into Microbial Signatures in Thrombi from Acute Ischemic Stroke Patients Undergoing Endovascular Treatment.Brain sciences · 2025Article
- Association between regular dental scaling and stroke risk in patients with periodontal diseases: evidence from a Korean nationwide database.Epidemiology and health · 2025Article
- Association between periodontal disease and systemic diseases: a cross-sectional analysis of current evidence.Military Medical Research · 2024Article
- Exploring the relationship between hemodynamics and the immune microenvironment in carotid atherosclerosis: Insights from CFD and CyTOF technologies.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Assessment of Relation between Periodontal Disease and Macular Degeneration.Journal of pharmacy & bioallied sciences · 2024Article
- The Impact of Peri-Implant Diseases on the General Status of Patients with Cardiovascular Diseases: A Literature Review.Life (Basel, Switzerland) · 2024Review
- Detecting prokaryote-specific gene and other bacterial signatures in thrombi from patients with acute ischemic stroke.Thrombosis journal · 2024Article
- The Anti-atherosclerosis Mechanism of Ziziphora clinopodioides Lam. Based On Network Pharmacology.Cell biochemistry and biophysics · 2023Article
- Localized periodontitis severity associated with carotid intima-media thickness in young adults: CHIEF atherosclerosis study.Scientific reports · 2023Article
- Is There a Link between COVID-19 Infection, Periodontal Disease and Acute Myocardial Infarction?Life (Basel, Switzerland) · 2021Review
- The 100 Most-Cited Articles on Periodontal Disease and Atherosclerosis: A Bibliometric Study (1989-2025).Journal of International Society of Preventive & Community DentistryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
backgroundInflammation plays a major role in the development and progression of cardiovascular disease (CVD) morbidity and mortality. The well-established relationship between periodontal disease (PD) and CVD may be causal. Left untreated, PD can lead to high systemic inflammation, thus contributing to inflammatory CVD, such as atherosclerosis. Multiple mechanisms have been proposed to elucidate the causal relationship between PD and its contribution to CVD.
objectiveThis review article highlights the current evidence supporting the role of PD in the development and progression of atherosclerosis.
methodsAfter creating a list of relevant medical subject heading (MeSH) terms, a systematic search within PubMed in English for each MeSH term between 2000 and 2019 was used to generate evidence for this review article.
conclusionThere is overwhelming evidence in the current literature that supports an association between PD and CVD that is independent of known CVD risk factors. However, the supporting evidence that PD directly causes CVD in humans continues to remain elusive. Multiple biologically plausible mechanisms have been proposed and investigated, yet most studies are limited to mouse models and in vitro cell cultures. Additional studies testing the various proposed mechanisms in longitudinal human studies are required to provide deeper insight into the mechanistic link between these 2 related diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.