Evidence map›Paper›PMID 32646433›Full record

ArticleBMC infectious diseases2020

Influence of blood group, Glucose-6-phosphate dehydrogenase and Haemoglobin genotype on Falciparum malaria in children in Vihiga highland of Western Kenya.

Jafaralli Sande Ahmed, Bernard Guyah, David Sang', Mark Kilongosi Webale, Nathan Shaviya Mufyongo, Elly Munde, Collins Ouma

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Coinheritance of polymorphic alleles ofOne health (Amsterdam, Netherlands) · 2025
    Article
  4. Article
  5. Article
  6. Genotyping of ABO and Duffy blood groups among malaria patients in Thailand.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jafaralli Sande AhmedDepartment of Biomedical Sciences and Technology, Maseno University, Maragoli, Kenya.
Bernard GuyahDepartment of Biomedical Sciences and Technology, Maseno University, Maragoli, Kenya.
David Sang'Department of Biomedical Sciences and Technology, Maseno University, Maragoli, Kenya.
Mark Kilongosi WebaleSchool of Health Sciences, Kirinyaga University, Kerugoya, Kenya.
Nathan Shaviya MufyongoDepartment of Biomedical Sciences and Technology, Masinde Muliro University of Science and Technology, Kakamega, Kenya.
Elly MundeSchool of Health Sciences, Kirinyaga University, Kerugoya, Kenya.
Collins OumaDepartment of Biomedical Sciences and Technology, Maseno University, Maragoli, Kenya. collinouma@yahoo.com.ORCID http://orcid.org/0000-0001-8205-8887
Maseno University · KEKirinyaga University · KEMasinde Muliro University of Science and Technology · KE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGenetic diversity of ABO blood, glucose-6-phosphate dehydrogenase (G6PD) deficiency and haemoglobin type and their ability to protect against malaria vary geographically, ethnically and racially. No study has been carried out in populations resident in malaria regions in western Kenya.

methodA total of 574 malaria cases (severe malaria anaemia, SMA = 137 and non-SMA = 437) seeking treatment at Vihiga County and Referral Hospital in western Kenya, were enrolled and screened for ABO blood group, G6PD deficiency and haemoglobin genotyped in a hospital-based cross-sectional study.

resultWhen compared to blood group O, blood groups A, AB and B were not associated with SMA (P = 0.380, P = 0.183 and P = 0.464, respectively). Further regression analysis revealed that the carriage of the intermediate status of G6PD was associated with risk to SMA (OR = 1.52, 95%CI = 1.029-2.266, P = 0.035). There was, however, no association between AS and SS with severe malaria anaemia. Co-occurrence of both haemoglobin type and G6PD i.e. the AA/intermediate was associated with risk to SMA (OR = 1.536, 95%CI = 1.007-2.343, P = 0.046) while the carriage of the AS/normal G6PD was associated with protection against SMA (OR = 0.337, 95%CI = 0.156-0.915, P = 0.031).

conclusionResults demonstrate that blood group genotypes do not have influence on malaria disease outcome in this region. Children in Vihiga with blood group O have some protection against malaria. However, the intermediate status of G6PD is associated with risk of SMA. Further, co-inheritance of sickle cell and G6PD status are important predictors of malaria disease outcome. This implies combinatorial gene function in influencing disease outcome.

Indexed as

GenotypeABO Blood-Group SystemChild, PreschoolCross-Sectional StudiesFemaleGlucosephosphate DehydrogenaseGlucosephosphate Dehydrogenase DeficiencyHemoglobinsHumansInfantKenyaMalaria, FalciparumMalePhenotypePlasmodium falciparumPolymorphism, GeneticABO Blood-Group SystemGlucosephosphate DehydrogenaseHemoglobinsChildrenGenetic variantsMalariaWestern Kenya

Identifiers

PMID32646433
PMCPMC7346653
OpenAlexW3041003184

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.