ArticleBMC genetics2020
Identification of candidate genes for milk production traits by RNA sequencing on bovine liver at different lactation stages.
Article in BMC genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 36 citations in OpenAlex.
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- Liver transcriptome dynamics in Holstein cows during the periparturient transition.Scientific reports · 2026Article
- Serum physiology, fecal microbiota, and metabolome signatures associated with perinatal stage transitions in Mongolian mares.Frontiers in veterinary science · 2026Article
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- From lactation to malignancy: A comparison between healthy and cancerous breast gland at single-cell resolution reveals new issues for tumorigenesis.FEBS letters · 2025Article
- Identification and characterization of gene networks and key genes related to the high-yield production of milk in high-yield cows using meta-analysis of microarray data.Biochemistry and biophysics reports · 2025Article
- Hepatic Transcriptome Reveals Potential Key Genes Contributing to Differential Milk Production.Genes · 2024Article
- Transcriptomic analysis reveals molecular insights into lactation dynamics in Jakhrana goat mammary gland.BMC genomics · 2024Article
- A transcriptomic analysis of skeletal muscle tissues reveals promising candidate genes and pathways accountable for different daily weight gain in Hanwoo cattle.Scientific reports · 2024Article
- Epigenetic aging in cows is accelerated by milk production.Epigenetics · 2023Article
- Integrated analysis of transcriptome and metabolome revealed biological basis of sows from estrus to lactation.iScience · 2023Article
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- Genomic patterns of homozygosity and inbreeding depression in Murciano-Granadina goats.Journal of animal science and biotechnology · 2022Article
- Identification and annotation of milk associated genes from milk somatic cells using expression and RNA-seq data.Bioinformation · 2022Article
- Sequence Variation in the Bovine Lipin-1 Gene (Animals : an open access journal from MDPI · 2021Article
- Associations between polymorphisms of SLC22A7, NGFR, ARNTL and PPP2R2B genes and Milk production traits in Chinese Holstein.BMC genomic data · 2021Article
- Article
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundRNA-sequencing was performed to explore the bovine liver transcriptomes of Holstein cows to detect potential functional genes related to lactation and milk composition traits in dairy cattle. The bovine transcriptomes of the nine liver samples from three Holstein cows during dry period (50-d prepartum), early lactation (10-d postpartum), and peak of lactation (60-d postpartum) were sequenced using the Illumina HiSeq 2500 platform.
resultsA total of 204, 147 and 81 differentially expressed genes (DEGs, p < 0.05, false discovery rate q < 0.05) were detected in early lactation vs. dry period, peak of lactation vs. dry period, and peak of lactation vs. early lactation comparison groups, respectively. Gene ontology and KEGG pathway analysis showed that these DEGs were significantly enriched in specific biological processes related to metabolic and biosynthetic and signaling pathways of PPAR, AMPK and p53 (p < 0.05). Ten genes were identified as promising candidates affecting milk yield, milk protein and fat traits in dairy cattle by using an integrated analysis of differential gene expression, previously reported quantitative trait loci (QTL), data from genome-wide association studies (GWAS), and biological function information. These genes were APOC2, PPP1R3B, PKLR, ODC1, DUSP1, LMNA, GALE, ANGPTL4, LPIN1 and CDKN1A.
conclusionThis study explored the complexity of the liver transcriptome across three lactation periods in dairy cattle by performing RNA sequencing. Integrated analysis of DEGs and reported QTL and GWAS data allowed us to find ten key candidate genes influencing milk production traits.
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