Evidence map›Paper›PMID 32646373›Full record

Observational studyBMC infectious diseases2020

Effect of a multi-dimensional case management model on anti-retroviral therapy-related outcomes among people living with human immunodeficiency virus in Beijing, China.

Lili Dai, Xiaochun Yu, Ying Shao, Yali Wang, Zaicun Li, Jiangzhu Ye, Shaoli Bai, Xiaoling Guo, Jianyun Wang, Bin Su and 6 more

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Lili DaiCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
Xiaochun YuSchool of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China.
Ying ShaoCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
Yali WangCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
Zaicun LiCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
Jiangzhu YeCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
Shaoli BaiLanzhou Municipality Pulmonary Hospital, Lanzhou, 730046, Gan Su, China.
Xiaoling GuoLanzhou Municipality Pulmonary Hospital, Lanzhou, 730046, Gan Su, China.
Jianyun WangLanzhou Municipality Pulmonary Hospital, Lanzhou, 730046, Gan Su, China.
Bin SuCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
Taiyi JiangCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
Tong ZhangCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
Hao WuCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
Sarah Robbins ScottThe National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 100037, China.
An LiuCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China. liuan75@163.com.
Lijun SunCenter for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China. sunlijunkity@163.com.
Capital Medical University · CNBeijing YouAn Hospital · CNPulmonary Hospital of Lanzhou · CNAnhui Medical University · CNChinese Center For Disease Control and Prevention · CN

Funding

National 13th Five-Year Grand Program on Key Infectious Disease Control 2017ZX10202101-004-001National 13th Five-Year Grand Program on Key Infectious Disease Control 2017ZX10202102-005-003National 13th Five-Year Grand Program on Key Infectious Disease Control 2018ZX10302-102National 13th Five-Year Grand Program on Key Infectious Disease Control 2018ZX10721102-003-003National Natural Science Foundation of China 81601795the National Natural Science Foundation of China 81772165
6 · The paper itself

Abstract

backgroundThis paper introduces a comprehensive case management model uniting doctors, nurses, and non-governmental organizations (NGOs) in order to shorten the time from HIV diagnosis to initiation of antiviral therapy, improve patients' adherence, and ameliorate antiretroviral treatment (ART)-related outcomes.

methodsAll newly diagnosed human immunodeficiency virus (HIV) cases at Beijing YouAn Hospital from January 2012 to December 2013 were selected as the control group, while all newly diagnosed HIV-infected patients from January 2015 to December 2016 were selected as the intervention group, receiving the comprehensive case management model.

results4906 patients were enrolled, of which 1549 were in the control group and 3357 in the intervention group. The median time from confirming HIV infection to ART initiation in the intervention group was 35 (18-133) days, much shorter than the control group (56 (26-253) days, P < 0.001). Participants in the intervention group had better ART adherence compared to those in the control group (intervention: 95.3%; control: 89.2%; p < 0.001). During the 2 years' follow-up, those receiving case management were at decreased odds of experiencing virological failure (OR: 0.27, 95%CI: 0.17-0.42, P < 0.001). Observed mortality was 0.4 deaths per 100 patient-years of follow-up for patients in the control group compared with 0.2 deaths per 100 patient-years of follow-up in the intervention group.

conclusionsPeople living with HIV engaged in the comprehensive case management model were more likely to initiate ART sooner and maintained better treatment compliance and improved clinical outcomes compared to those who received routine care. A comprehensive case management program could be implemented in hospitals across China in order to reduce the HIV disease burden in the country.

Indexed as

Case ManagementTime-to-TreatmentAcquired Immunodeficiency SyndromeAdultAnti-Retroviral AgentsBeijingFemaleFollow-Up StudiesHIV-1HumansMaleMedication AdherenceMiddle AgedRetention in CareRetrospective StudiesSurvival RateAnti-Retroviral AgentsCase managementHIVRetention rateVirologic failure

Identifiers

PMID32646373
PMCPMC7350672
OpenAlexW3041258152

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.