ReviewClinical and molecular hepatology2020
Liver graft from donation after circulatory death donor: Real practice to improve graft viability.
Review in Clinical and molecular hepatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- A pilot, two-center, sequential dose escalation safety study of alteplase with fresh frozen plasma during normothermic liver perfusion.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2026Trial
- Intraoperative blood loss as a predictor of outcomes in liver transplantation: determining optimal cutoff values for improved graft survival.Langenbeck's archives of surgery · 2025Observational
- The Impact of Normothermic Machine Perfusion on Biliary Complications in Donation After Circulatory Death Donor Liver Transplantation.Transplantation direct · 2025Article
- Rutaecarpine alleviates hepatic ischemia‒reperfusion injury in liver transplantation by inhibiting inflammatory response and oxidative stress.Frontiers in pharmacology · 2025Article
- Optimizing DCD Liver Grafts With Prolonged Warm Ischemic Time Using Stabilized Plasmin in a Static Cold Storage Orthotopic Rat Liver Transplant Model.Transplantation direct · 2024Article
- Current Understanding of Marginal Grafts in Liver Transplantation.Aging and disease · 2024Review
- Anesthetic Considerations of Organ Procurement After Brain and Cardiac Death: A Narrative Review.Cureus · 2023Review
- DCD liver transplant in patients with a MELD over 35.Frontiers in immunology · 2023Article
- The first successful report of liver transplantation from category III donation after circulatory death in South Korea: a case report.Korean journal of transplantation · 2022Article
- Comparison of Biliary Complications Rates After Brain Death, Donation After Circulatory Death, and Living-Donor Liver Transplantation: A Single-Center Cohort Study.Transplant international : official journal of the European Society for Organ Transplantation · 2022Article
- The Immunological Basis of Liver Allograft Rejection.Frontiers in immunology · 2020Review
- Predicting massive blood transfusions in liver transplantation: the McCluskey Risk Index revised 20 years later.Blood transfusion = Trasfusione del sangueObservational
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Donation after circulatory death (DCD) is an increasing source of liver grafts for transplantation, yet outcomes have been inferior compared to donation after brain death liver transplantation. These worse outcomes are mainly due to the severe graft injury resulting from mandatory warm ischemia during DCD organ recovery. New evidence, however, indicates that improved donor selection and surgical techniques can decrease the risk of graft failure and ischemic cholangiopathy (IC). Under current best practices, DCD organs are retrieved with the super-rapid technique, optimizing timing and protecting the liver graft from detrimental warm ischemia. Graft viability is influenced by both the quantity and quality of warm ischemia, which is unique to each donor and causes various degrees of pathophysiologic consequences. Evidence also shows that the choice of preservation solution and premortem heparin administration influences graft viability. Additionally, although the precise mechanism of IC remains unknown, stasis of blood during donor warm ischemia may cause the formation of microthrombi in the peribiliary vascular plexus and ischemia of the bile duct. Importantly, thrombolytic protocols show a possible preventive modality for IC. Finally, while ex vivo machine perfusion technology has gained an interest in DCD liver transplantation, further studies are necessary to evaluate the effectiveness of this evolving field to improve graft quality and transplant outcomes.
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