Evidence map›Paper›PMID 32645919›Full record

ArticleCells2020

Basophils from Cancer Patients Respond to Immune Stimuli and Predict Clinical Outcome.

Heather J Bax, Jitesh Chauhan, Chara Stavraka, Atousa Khiabany, Mano Nakamura, Giulia Pellizzari, Kristina M Ilieva, Sara Lombardi, Hannah J Gould, Christopher J Corrigan and 10 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Immune cells mediate the causal pathway linking circulating complements to cancer: A Mendelian randomization study.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
    Pooled it
  2. Review
  3. Review
  4. AllergoOncology in Review: Harnessing Allergy in the Field of Oncology to Improve Patient Outcomes.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. TSLP: contrasting roles in cancer.Frontiers in immunology · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 1 country.

Heather J BaxSt. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, London SE1 9RT, UK.ORCID 0000-0003-0432-4160
Jitesh ChauhanSt. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, London SE1 9RT, UK.
Chara StavrakaSt. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, London SE1 9RT, UK.ORCID 0000-0001-7623-299X
Atousa KhiabanySt. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, London SE1 9RT, UK.
Mano NakamuraSt. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, London SE1 9RT, UK.
Giulia PellizzariSt. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, London SE1 9RT, UK.
Kristina M IlievaSt. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, London SE1 9RT, UK.
Sara LombardiGuy's and St Thomas' Oncology & Haematology Clinical Trials (OHCT), Guy's Cancer Centre, London SE1 9RT, UK.
Hannah J GouldRandall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences, King's College London, London SE1 9RT, UK.
Christopher J CorriganAsthma UK Centre, Allergic Mechanisms in Asthma, King's College London, London SE1 9RT, UK.ORCID 0000-0002-0706-6534
Stephen J TillAsthma UK Centre, Allergic Mechanisms in Asthma, King's College London, London SE1 9RT, UK.
Sidath KatugampolaCentre for Drug Development, Cancer Research UK, 2 Redman Place, London E20 1JQ, UK.ORCID 0000-0002-8525-045X
Paul S JonesCentre for Drug Development, Cancer Research UK, 2 Redman Place, London E20 1JQ, UK.
Claire BartonCentre for Drug Development, Cancer Research UK, 2 Redman Place, London E20 1JQ, UK.
Anna WinshipDepartments of Medical Oncology and Clinical Oncology, Guy's and St Thomas' NHS Foundation Trust, London SE1 9RT, UK.
Sharmistha GhoshDepartments of Medical Oncology and Clinical Oncology, Guy's and St Thomas' NHS Foundation Trust, London SE1 9RT, UK.
Ana MontesDepartments of Medical Oncology and Clinical Oncology, Guy's and St Thomas' NHS Foundation Trust, London SE1 9RT, UK.
Debra H JosephsSt. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, London SE1 9RT, UK.
James F SpicerSchool of Cancer & Pharmaceutical Sciences, King's College London, Guy's Hospital, London SE1 9RT, UK.
Sophia N KaragiannisSt. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, London SE1 9RT, UK.ORCID 0000-0002-4100-7810
King's College London · GBGuy's Hospital · GBCancer Research UK · GBGuy's and St Thomas' NHS Foundation Trust · GB

Funding

Cancer Research UK C10355/A15587Cancer Research UK C30122/A11527Cancer Research UK C30122/A15774Medical Research Council G0200486Medical Research Council G0501494Medical Research Council G1000758Medical Research Council G1100090Medical Research Council MR/L023091/1
6 · The paper itself

Abstract

Basophils are involved in manifestations of hypersensitivity, however, the current understanding of their propensity for activation and their prognostic value in cancer patients remains unclear. As in healthy and atopic individuals, basophil populations were identified in blood from ovarian cancer patients (

Indexed as

BasophilsBiomarkers, TumorFemaleFlow CytometryHumansImmunoglobulin EImmunophenotypingOvarian NeoplasmsTetraspanin 30Biomarkers, TumorCD63 protein, humanImmunoglobulin ETetraspanin 30antibodiesbasophilsBATbiomarkersCD63chemotherapyhypersensitivityIgEovarian cancersurvival

Identifiers

PMID32645919
PMCPMC7408103
OpenAlexW3039559566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.