Evidence map›Paper›PMID 32645898›Full record

ArticleCancers2020

Prospective Assessment of Systemic MicroRNAs as Markers of Response to Neoadjuvant Chemotherapy in Breast Cancer.

Andrew McGuire, Maire-Caitlin Casey, Ronan M Waldron, Helen Heneghan, Olga Kalinina, Emma Holian, Ailbhe McDermott, Aoife J Lowery, John Newell, Róisín M Dwyer and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
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  7. Article
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  9. Article
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  13. Interplay between LncRNAs and microRNAs in Breast Cancer.International journal of molecular sciences · 2023
    Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Targeting non-coding RNAs to overcome cancer therapy resistance.Signal transduction and targeted therapy · 2022
    Review
  20. Combinatorial Power of cfDNA, CTCs and EVs in Oncology.Diagnostics (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Andrew McGuireDiscipline of Surgery, School of Medicine, Lambe Institute for Translational Research, National University of Ireland Galway, Galway H91 YR71, Ireland.
Maire-Caitlin CaseyDiscipline of Surgery, School of Medicine, Lambe Institute for Translational Research, National University of Ireland Galway, Galway H91 YR71, Ireland.
Ronan M WaldronDiscipline of Surgery, School of Medicine, Lambe Institute for Translational Research, National University of Ireland Galway, Galway H91 YR71, Ireland.
Helen HeneghanDiscipline of Surgery, School of Medicine, Lambe Institute for Translational Research, National University of Ireland Galway, Galway H91 YR71, Ireland.
Olga KalininaSchool of Mathematics, Statistics and Applied Mathematics, National University of Ireland Galway, Galway H91 TK33, Ireland.
Emma HolianSchool of Mathematics, Statistics and Applied Mathematics, National University of Ireland Galway, Galway H91 TK33, Ireland.ORCID 0000-0003-1763-7422
Ailbhe McDermottDiscipline of Surgery, School of Medicine, Lambe Institute for Translational Research, National University of Ireland Galway, Galway H91 YR71, Ireland.
Aoife J LoweryDiscipline of Surgery, School of Medicine, Lambe Institute for Translational Research, National University of Ireland Galway, Galway H91 YR71, Ireland.
John NewellSchool of Mathematics, Statistics and Applied Mathematics, National University of Ireland Galway, Galway H91 TK33, Ireland.
Róisín M DwyerDiscipline of Surgery, School of Medicine, Lambe Institute for Translational Research, National University of Ireland Galway, Galway H91 YR71, Ireland.ORCID 0000-0002-5854-0339
Nicola MillerDiscipline of Surgery, School of Medicine, Lambe Institute for Translational Research, National University of Ireland Galway, Galway H91 YR71, Ireland.
Maccon KeaneDepartment of Medical Oncology, Galway University Hospital, Galway H71 YR71, Ireland.
James A L BrownDiscipline of Surgery, School of Medicine, Lambe Institute for Translational Research, National University of Ireland Galway, Galway H91 YR71, Ireland.ORCID 0000-0002-3155-0334
Michael J KerinDiscipline of Surgery, School of Medicine, Lambe Institute for Translational Research, National University of Ireland Galway, Galway H91 YR71, Ireland.
Ollscoil na Gaillimhe – University of Galway · IEUniversity Hospital Galway · IE

Funding

Breast Cancer Research N/A
6 · The paper itself

Abstract

Neoadjuvant chemotherapy (NACT) is used in locally advanced breast cancer to reduce tumour burden prior to surgical resection. However, only a subset of NACT treated patients will respond to treatment or achieve a pathologic complete response (pCR). This multicenter, prospective study (CTRIAL-IE (ICORG) 10-11 study) evaluated circulating microRNA as novel non-invasive prognostic biomarkers of NACT response in breast cancer. Selected circulating microRNAs (Let-7a, miR-21, miR-145, miR-155, miR-195) were quantified from patients undergoing standard of care NACT treatment (

Indexed as

biomarkerbreastchemotherapymicroRNAneoadjuvantprognostic

Identifiers

PMID32645898
PMCPMC7408914
OpenAlexW3039896509

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.