Evidence map›Paper›PMID 32645849›Full record

ArticleCells2020

Adenosine and Metabotropic Glutamate Receptors Are Present in Blood Serum and Exosomes from SAMP8 Mice: Modulation by Aging and Resveratrol.

Alejandro Sánchez-Melgar, José Luis Albasanz, Christian Griñán-Ferré, Mercè Pallàs, Mairena Martín

Open access · goldAbstract read
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Extracellular Vesicles in Tauopathies: Mechanisms and Applications.International journal of molecular sciences · 2026
    Review
  2. Frontiers in cellular neuroscience · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Alejandro Sánchez-MelgarDepartment of Inorganic, Organic and Biochemistry, Faculty of Chemical and Technological Sciences, School of Medicine of Ciudad Real, Regional Center of Biomedical Research (CRIB), University of Castilla- La Mancha (UCLM), 13071 Ciudad Real, Spain.
José Luis AlbasanzDepartment of Inorganic, Organic and Biochemistry, Faculty of Chemical and Technological Sciences, School of Medicine of Ciudad Real, Regional Center of Biomedical Research (CRIB), University of Castilla- La Mancha (UCLM), 13071 Ciudad Real, Spain.ORCID 0000-0002-9927-5076
Christian Griñán-FerréDepartment of Pharmacology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, Institute of Neuroscience, University of Barcelona, 08028 Barcelona, Spain.ORCID 0000-0002-5424-9130
Mercè PallàsDepartment of Pharmacology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, Institute of Neuroscience, University of Barcelona, 08028 Barcelona, Spain.ORCID 0000-0003-3095-4254
Mairena MartínDepartment of Inorganic, Organic and Biochemistry, Faculty of Chemical and Technological Sciences, School of Medicine of Ciudad Real, Regional Center of Biomedical Research (CRIB), University of Castilla- La Mancha (UCLM), 13071 Ciudad Real, Spain.
University of Castilla-La Mancha · ESUniversitat de Barcelona · ES

Funding

MEASURING SUBSTANCE ABUSE AMONG THE DEAFR43DA008002 · NIDA · SOCIAL SCIENCES INNOVATIONS CORPORATION · PI GOLDSTEIN, MARJORIE F · 1992 to 1992
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MEASUREMENT OF SUBSTANCE ABUSE AMONG THE DEAFR44DA008002 · NIDA · SOCIAL SCIENCES INNOVATIONS CORPORATION · PI ECKHARDT, ELIZABETH F · 1994 to 1997
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6 · The paper itself

Abstract

Adenosine (ARs) and metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors (GPCRs) that are modulated in the brain of SAMP8 mice, an animal model of Alzheimer's disease (AD). In the present work, it is shown the presence of ARs and mGluRs in blood serum and derived exosomes from SAMP8 mice as well as its possible modulation by aging and resveratrol (RSV) consumption. In blood serum, adenosine A

Indexed as

AdenosineAgingAlzheimer DiseaseAnimalsBlotting, WesternChromatography, High Pressure LiquidExosomesMaleMiceReceptor, Adenosine A1Receptors, Adenosine A2Receptors, Metabotropic GlutamateResveratrolAdenosineReceptor, Adenosine A1Receptors, Adenosine A2Receptors, Metabotropic GlutamateResveratroladenosine receptorsAlzheimer’s diseaseblood serumexosomesG-protein coupled receptorsmetabotropic glutamate receptorsresveratrolSAMP8 mice

Identifiers

PMID32645849
PMCPMC7407497
OpenAlexW3040068215

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.