ReviewCurrent opinion in structural biology2020
Local resolution estimates of cryoEM reconstructions.
Review in Current opinion in structural biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- Cryo-electron microscopy structure of a zinc uptake ABC transporter.Structure (London, England : 1993) · 2026Article
- Cryo-electron microscopy structure of a zinc uptake ABC transporter.bioRxiv : the preprint server for biology · 2025Article
- Assessing scoring metrics for AlphaFold2 and AlphaFold3 protein complex predictions.Protein science : a publication of the Protein Society · 2025Article
- Rescaling FSC curves.Acta crystallographica. Section D, Structural biology · 2025Article
- Article
- A robust normalized local filter to estimate compositional heterogeneity directly from cryo-EM maps.Nature communications · 2023Article
- New measures of anisotropy of cryo-EM maps.Nature methods · 2023Article
- Structural mechanism of intracellular autoregulation of zinc uptake in ZIP transporters.Nature communications · 2023Article
- Structural basis for enzymatic terminal C-H bond functionalization of alkanes.Nature structural & molecular biology · 2023Article
- Article
- Emerging Themes in CryoEM─Single Particle Analysis Image Processing.Chemical reviews · 2022Review
- Cryo-EM structure of transmembrane AAA+ protease FtsH in the ADP state.Communications biology · 2022Article
- Pore structure controls stability and molecular flux in engineered protein cages.Science advances · 2022Article
- Steerable Near-Quadrature Filter Pairs in Three Dimensions.SIAM journal on imaging sciences · 2022Article
- Advances in Xmipp for Cryo-Electron Microscopy: From Xmipp to Scipion.Molecules (Basel, Switzerland) · 2021Article
- Structural basis for SARS-CoV-2 envelope protein recognition of human cell junction protein PALS1.Nature communications · 2021Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The field of cryoEM has quickly advanced in last years with the new biochemical, technological, methodological and computational developments. It has allowed significant progresses in Structural Biology, typically reaching quasi-atomic resolutions in the reconstructed maps. However, this rapid advance has also generated new questions relevant to resolution estimates. The global resolution metrics and their criteria have been deeply discussed in the last decade, but despite that, it remains as an important issue in the field. Recently, the introduction of local resolution measurements has changed how cryoEM reconstructions are interpreted, providing information about the existence of heterogeneity, flexibility, and angular assignment errors, and using it as a tool to aid in modeling. In this review we revisit the concept of local resolution and the different algorithms in the current state of the art. However, the concept of local resolution is not uniquely defined, and each implementation measures different features. This may lead to inappropriate interpretation of local resolution maps. Hence, a set of good practices is provided in this review to avoid misleading and over-interpretation of the reconstructions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.