Evidence map›Paper›PMID 32645383›Full record

ArticleEuropean journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V2020

Charge reversible hyaluronic acid-modified dendrimer-based nanoparticles for siMDR-1 and doxorubicin co-delivery.

Xin Zhang, Jiayi Pan, Momei Yao, Livia Palmerston Mendes, Can Sarisozen, Shirui Mao, Vladimir P Torchilin

Open access · greenAbstract read
In one paragraph

Article in European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 45 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Mechanisms and challenges of nanocarriers as non-viral vectors of therapeutic genes for enhanced pulmonary delivery.Journal of controlled release : official journal of the Controlled Release Society · 2022
    Review
  6. Review
  7. Review
  8. Review
  9. Charge reversal nano-systems for tumor therapy.Journal of nanobiotechnology · 2022
    Review
  10. Review
  11. Review
  12. Review
  13. CD44-Targeted Nanocarrier for Cancer Therapy.Frontiers in pharmacology · 2021
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 4 countries.

Xin ZhangSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China; Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA.
Jiayi PanCenter for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA.
Momei YaoCenter for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA.
Livia Palmerston MendesCenter for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA; CAPES Foundation, Ministry of Education of Brazil, Brasilia 70040-020, Brazil.
Can SarisozenCenter for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA.
Shirui MaoSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: maoshirui@syphu.edu.cn.
Vladimir P TorchilinCenter for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA; Department of Oncology, Radiotherapy and Plastic Surgery, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia. Electronic address: v.torchilin@northeastern.edu.
Northeastern University · USShenyang Pharmaceutical University · CNSechenov University · RU

Funding

Lipid-dendrimer micellar nanocarriers for siRNA/drug co-delivery in MDR cancerR01CA200844 · NCI · NORTHEASTERN UNIVERSITY · PI TORCHILIN, VLADIMIR P · 2016 to 2020
$1.7M
NCI NIH HHS R01 CA200844
6 · The paper itself

Abstract

Dendrimer-based nanoparticles have shown promising applications in delivery of small interference RNA (siRNA) to downregulate proteins that contribute to multidrug resistance (MDR). Various types of modification can further enhance the anti-tumor efficacy of dendrimer-based nanoparticles. In this study, generation 4 polyamodoamine (PAMAM) was conjugated with PEG

Indexed as

Antibiotics, AntineoplasticCell Line, TumorCell SurvivalDendrimersDose-Response Relationship, DrugDoxorubicinDrug Delivery SystemsDrug Resistance, MultipleHCT116 CellsHumansHyaluronic AcidNanoparticlesAntibiotics, AntineoplasticDendrimersDoxorubicinHyaluronic AcidCo-delivery systemDoxorubicin base (Dox)Hyaluronic acid (HA)Mixed dendrimer micelles (MDMs)Multidrug resistancePAMAM dendrimerssiMDR-1

Identifiers

PMID32645383
PMCPMC9364115
OpenAlexW3040576305

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.