ArticleMolecular cell2020
Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling.
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Article in Molecular cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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52citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
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Who cites it
52 citing papers in PubMed, 82 citations in OpenAlex.
- A multivalent docking platform and Rcn1-mediated inhibition control the extent of calcineurin recruitment to the cell division site for the dephosphorylation of multiple cytokinetic proteins.bioRxiv : the preprint server for biology · 2026Article
- Two Faces of NFAT Transcription Factors in LymphocytesBiomolecules · 2026Review
- Hierarchical decoding of targeting tripeptide motif by the cytosolic iron-sulfur cluster assembly targeting complex.bioRxiv : the preprint server for biology · 2026Article
- Article
- The clinical missense variant E282K in PPP3CA/calcineurin shifts substrate dephosphorylation by altering active site recruitment.Nature communications · 2026Article
- Synthetic trap-peptides identify a TOM complex phosphatase - PP2A dephosphorylates Tom6.The FEBS journal · 2026Article
- A composite motif in calcimembrin/C16orf74 dictates multimeric dephosphorylation by calcineurin.Nature communications · 2025Article
- Thermoregulation network governing virulence of a critical human fungal pathogen.bioRxiv : the preprint server for biology · 2025Article
- Combination of in vivo and in vitro phosphoproteomics determines the PP2A target repertoire on proteome scale.Cell reports methods · 2025Article
- Calcineurin targets that mediateProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Sleep prevents brain phosphoproteome disruption to safeguard survival.Cell discovery · 2025Article
- The microprotein C16orf74/MICT1 promotes thermogenesis in brown adipose tissue.The EMBO journal · 2025Article
- PP2A-B56α is a key determinant of cardiac protein phosphorylation and functional responses to β-adrenergic signalling.Journal of molecular and cellular cardiology plus · 2025Article
- Calcineurin controls the cytokinesis machinery during thermal stress inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Phosphatase-independent activity of smooth-muscle calcineurin orchestrates a gene expression program leading to hypertension.PLoS biology · 2025Article
- The Myotubularin Related Proteins and the Untapped Interaction Potential of Their Disordered C-Terminal Regions.Proteins · 2025Article
- Combining cryo-electron microscopy (cryo-EM) with orthogonal solution state methods to define the molecular basis of the phosphoprotein phosphatase family regulation and substrate specificity.Current opinion in structural biology · 2025Review
- Calcineurin governs baseline and homeostatic regulations of non-rapid eye movement sleep in mice.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Hierarchical metabolic engineering for rewiring cellular metabolism.FEMS microbiology reviews · 2025Review
- Article
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Authors and funding
21 authors at 11 institutions in 6 countries.
Callie P WigingtonDepartment of Biology, Stanford University, Stanford, CA, USA.
Jagoree RoyDepartment of Biology, Stanford University, Stanford, CA, USA.
Nikhil P DamleDepartment of Biology, Stanford University, Stanford, CA, USA.
Vikash K YadavDepartment of Chemistry - BMC, Uppsala University, Uppsala, Sweden.
Cecilia BlikstadDepartment of Chemistry - BMC, Uppsala University, Uppsala, Sweden.
Eduard ReschFraunhofer Institute for Molecular Biology and Applied Ecology IME, Branch for Translational Medicine and Pharmacology TMP, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.
Cassandra J WongLunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
Douglas R MackayDepartment of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Jennifer T WangDepartment of Biology, Stanford University, Stanford, CA, USA.
Izabella KrystkowiakConway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.
Devin A BradburnDepartment of Biology, Stanford University, Stanford, CA, USA.
Eirini TsekitsidouDepartment of Biology, Stanford University, Stanford, CA, USA.
Su Hyun HongDepartment of Plant Biology, Carnegie Institution for Science, Stanford, CA, USA.
Malika Amyn KaderaliDepartment of Plant Biology, Carnegie Institution for Science, Stanford, CA, USA.
Shou-Ling XuDepartment of Plant Biology, Carnegie Institution for Science, Stanford, CA, USA.
Tim StearnsDepartment of Biology, Stanford University, Stanford, CA, USA.
Anne-Claude GingrasLunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, M5S 3H7 ON, Canada.
Katharine S UllmanDepartment of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Ylva IvarssonDepartment of Chemistry - BMC, Uppsala University, Uppsala, Sweden.
Norman E DaveyDivision of Cancer Biology, The Institute of Cancer Research, 237 Fullham Road, London SW3 6JB, UK.
Martha S CyertDepartment of Biology, Stanford University, Stanford, CA, USA. Electronic address: mcyert@stanford.edu.
Stanford University · USUppsala University · SEDepartment of Plant Biology · USCarnegie Institution for Science · USFraunhofer Institute for Molecular Biology and Applied Ecology · DEHuntsman Cancer Institute · USInstitute of Cancer Research · GBLunenfeld-Tanenbaum Research Institute · CAUniversity College Dublin · IEUniversity of Toronto · CAUniversity of Utah · US
Funding
Supplement to Enhance Wellness and Resiliency in the Graduate EnvironmentT32GM007276 · NIGMS · STANFORD UNIVERSITY · PI MORRISON, ASHBY J. · 1985 to 2023
$32.9MSystematic elucidation of calcineurin phosphatase signaling in humansR35GM136243 · NIGMS · STANFORD UNIVERSITY · PI Martha S. Cyert · 2020 to 2026
$3.9MStructure and mechanism of the centrosome-cilium complexR35GM130286 · NIGMS · STANFORD UNIVERSITY · PI STEARNS, TIM · 2019 to 2023
$3.4MDynamic Events at the Nuclear Envelope during Mitosis and InterphaseR01GM131052 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ULLMAN, KATHARINE S · 2019 to 2025
$2.1MIdentifying The Human Calcineurin Signaling NetworkR01GM119336 · NIGMS · STANFORD UNIVERSITY · PI CYERT, MARTHA S. · 2016 to 2019
$2.0MNutrient regulation of Alternative splicing and transcription by O-GlcNAcylationR01GM135706 · NIGMS · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI XU, SHOULING · 2020 to 2024
$1.8MMolecular mechanisms of centriolar triplet microtubule formationK99GM131024 · NIGMS · STANFORD UNIVERSITY · PI WANG, JENNIFER TONG · 2019 to 2021
$272kIdentification of novel substrates and functions of Calcineurin in human cellsF32GM120916 · NIGMS · STANFORD UNIVERSITY · PI WIGINGTON, CALLIE PREAST · 2016 to 2017
$113kCIHR FDN143301NIGMS NIH HHS F32 GM120916NIGMS NIH HHS K99 GM131024NIGMS NIH HHS R01 GM119336NIGMS NIH HHS R01 GM131052NIGMS NIH HHS R01 GM135706NIGMS NIH HHS R35 GM130286NIGMS NIH HHS R35 GM136243NIGMS NIH HHS T32 GM007276
Abstract
Short linear motifs (SLiMs) drive dynamic protein-protein interactions essential for signaling, but sequence degeneracy and low binding affinities make them difficult to identify. We harnessed unbiased systematic approaches for SLiM discovery to elucidate the regulatory network of calcineurin (CN)/PP2B, the Ca
Indexed as
Active Transport, Cell NucleusAmino Acid MotifsBiotinylationCalcineurinCentrosomeComputer SimulationHEK293 CellsHeLa CellsHumansMass SpectrometryNuclear Pore Complex ProteinsPhosphoric Monoester HydrolasesPhosphorylationProtein Interaction MapsProteomeReceptor, Notch1Calcineurincalcineurin phosphataseNOTCH1 protein, humanNuclear Pore Complex ProteinsNUP153 protein, humanPhosphoric Monoester HydrolasesProteomeReceptor, Notch1Saccharomyces cerevisiae Proteinscalcineurincalcium signalingcentrosomein silico motif discoveryNotch1NPCnuclear pore complexProP-PDprotein phosphataseproteomic peptide phage displayproximity-dependent biotinylationShort Linear MotifSLiM
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