Evidence map›Paper›PMID 32645303›Full record

ArticleNeuron2020

Unexpected Synergy: Macrophages and Schwann Cells Modulate Pathology in a Newborn Disease through a Shared Substrate.

Panagiotis Kratimenos, Vittorio Gallo

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 17 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Panagiotis KratimenosCenter for Neuroscience Research, Children's National Research Institute, Washington, DC 20010, USA; Division of Neonatology, Children's National Hospital, Washington, DC 20010, USA; Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA.
Vittorio GalloCenter for Neuroscience Research, Children's National Research Institute, Washington, DC 20010, USA; Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA; Department of Pharmacology and Physiology, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA. Electronic address: vgallo@childrensnational.org.
Children's National · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Krabbe disease is characterized by GALC deficiency and Schwann cell impairment. In a recent issue of Neuron, Weinstock et al. (2020) show that hematopoietic stem cell transplantation, an established therapy, improves pathology in a mouse model through an unexpected GALC-dependent mechanism, i.e., by providing functional macrophages capable of phagocytosis, rather than by supplying GALC for Schwann cell function.

Indexed as

Leukodystrophy, Globoid CellAnimalsDisease Models, AnimalGalactosylceramidaseHumansInfant, NewbornMacrophagesMiceSchwann CellsGalactosylceramidase

Identifiers

PMID32645303
OpenAlexW3041475936

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.