ArticleBiophysical journal2020
Coarse-Grained Modeling of Pore Dynamics on the Red Blood Cell Membrane under Large Deformations.
Article in Biophysical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Shear-Responsive Red Blood Cell Carriers for Targeted Drug Delivery to Constricted Arteries.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- A parametric study of mechanoporation through microfluidic design to modulate shear, compressive, and adhesion forces and loading rates.Lab on a chip · 2026Article
- Multi-scale simulation of red blood cell trauma in large-scale high-shear flows after Norwood operation.Computer methods and programs in biomedicine · 2025Article
- Effect of intercellular collisions on red blood cell membrane damage.Scientific reports · 2025Article
- Recent advances in microscale techniques for red blood cells manipulation.Biomicrofluidics · 2025Review
- The dynamics of red blood cells traversing slits of mechanical heart valves under high shear.Biophysical journal · 2024Article
- Acoustofluidic Engineering of Functional Vessel-on-a-Chip.ACS biomaterials science & engineering · 2023Article
- Red blood cells: a potential delivery system.Journal of nanobiotechnology · 2023Review
- Article
- Coarse-grained molecular simulation of extracellular vesicle squeezing for drug loading.Physical chemistry chemical physics : PCCP · 2023Article
- Recent Advances in Computational Modeling of Biomechanics and Biorheology of Red Blood Cells in Diabetes.Biomimetics (Basel, Switzerland) · 2022Article
- Computational investigation of blood cell transport in retinal microaneurysms.PLoS computational biology · 2022Article
- Computational modeling of biomechanics and biorheology of heated red blood cells.Biophysical journal · 2021Article
- How the spleen reshapes and retains young and old red blood cells: A computational investigation.PLoS computational biology · 2021Article
- Small molecule therapeutics to destabilize the ACE2-RBD complex: A molecular dynamics study.Biophysical journal · 2021Article
- Numerical simulation of intracellular drug delivery via rapid squeezing.Biomicrofluidics · 2021Article
- Small Molecules to Destabilize the ACE2-RBD Complex: A Molecular Dynamics Study for Potential COVID-19 Therapeutics.ChemRxiv : the preprint server for chemistry · 2020Article
- Quantitative absorption imaging of red blood cells to determine physical and mechanical properties.RSC advances · 2020Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Transient pore formation on the membrane of red blood cells (RBCs) under high mechanical tensions is of great importance in many biomedical applications, such as RBC damage (hemolysis) and mechanoporation-based drug delivery. The dynamic process of pore formation, growth, and resealing is hard to visualize in experiments. We developed a mesoscale coarse-grained model to study the characteristics of transient pores on a patch of the lipid bilayer that is strengthened by an elastic meshwork representing the cytoskeleton. Unsteady molecular dynamics was used to study the pore formation and reseal at high strain rates close to the physiological ranges. The critical strain for pore formation, pore characteristics, and cytoskeleton effects were studied. Results show that the presence of the cytoskeleton increases the critical strain of pore formation and confines the pore growth. Moreover, the pore recovery process under negative strain rates (compression) is analyzed. Simulations show that pores can remain open for a long time during the high-speed tank-treading induced stretching and compression process that a patch of the RBC membrane usually experiences under high shear flow. Furthermore, complex loading conditions can affect the pore characteristics and result in denser pores. Finally, the effects of strain rate on pore formation are analyzed. Higher rate stretching of membrane patch can result in a significant increase in the critical areal strain and density of pores. Such a model reveals the dynamic molecular process of RBC damage in biomedical devices and mechanoporation that, to our knowledge, has not been reported before.
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