ArticlePloS one2020
REM sleep is associated with white matter integrity in cognitively healthy, older adults.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Tract-specific white matter changes and their cognitive correlates in obstructive sleep apnea: a cross-sectional study using 3.0 T diffusion tensor imaging.Sleep & breathing = Schlaf & Atmung · 2026Article
- REM Sleep is Associated with Cognition and Biomarkers Longitudinally in Older Adults Across the Alzheimer Disease Continuum.medRxiv : the preprint server for health sciences · 2026Article
- Blood measure of neuronal death is exponentially higher with age, especially in females, and halted in Alzheimer's disease by GM-CSF treatment.Cell reports. Medicine · 2026Article
- Demyelination and Cognitive Performance in Long COVID Patients with Insomnia and/or Depression.International journal of molecular sciences · 2025Article
- Objective sleep monitoring at home in older adults: A scoping review.Journal of sleep research · 2025Article
- Impact of Alzheimer's disease on sleep in adults with Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Sleep Across the Lifespan: A Neurobehavioral Perspective.Current sleep medicine reports · 2025Review
- Reduced rapid eye movement sleep in late middle-aged and older apolipoprotein E ɛ4 allele carriers.Sleep · 2024Article
- The importance of rapid eye movement sleep and its implications for Alzheimer's disease.Sleep · 2024Article
- Circadian rapid eye movement sleep expression is associated with brain microstructural integrity in older adults.Communications biology · 2024Article
- Association between self-perception of the neighborhood environment and sleep problems in older Brazilian adults: findings from ELSI-Brazil.Cadernos de saude publica · 2024Article
- Article
- Association between the Pittsburgh sleep quality index and white matter integrity in healthy adults: a whole-brain magnetic resonance imaging study.Sleep and biological rhythms · 2023Article
- Association of white matter volume with sleep quality: a voxel-based morphometry study.Brain imaging and behavior · 2022Article
- Neural correlates of sleep quality in children: Sex-specific associations shown by brain diffusion tractography.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022Article
- An Improved Model of Moderate Sleep Apnoea for Investigating Its Effect as a Comorbidity on Neurodegenerative Disease.Frontiers in aging neuroscience · 2022Article
- Nighttime Sleep Characteristics and White Matter Integrity in Young Adults.Nature and science of sleep · 2022Article
- White matter microstructure and sleep-wake disturbances in individuals at ultra-high risk of psychosis.Frontiers in human neuroscience · 2022Article
- Individual differences in slow wave sleep architecture relate to variation in white matter microstructure across adulthood.Frontiers in aging neuroscience · 2022Article
- Pittsburgh Sleep Quality Index (PSQI) responses are modulated by total sleep time and wake after sleep onset in healthy older adults.PloS one · 2022Article
Corrections and comments
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Authors and funding
17 authors at 2 institutions in 1 country.
Funding
Abstract
There is increasing awareness that self-reported sleep abnormalities are negatively associated with brain structure and function in older adults. Less is known, however, about how objectively measured sleep associates with brain structure. We objectively measured at-home sleep to investigate how sleep architecture and sleep quality related to white matter microstructure in older adults. 43 cognitively normal, older adults underwent diffusion tensor imaging (DTI) and a sleep assessment within a six-month period. Participants completed the PSQI, a subjective measure of sleep quality, and used an at-home sleep recorder (Zeo, Inc.) to measure total sleep time (TST), sleep efficiency (SE), and percent time in light sleep (LS), deep sleep (DS), and REM sleep (RS). Multiple regressions predicted fractional anisotropy (FA) and mean diffusivity (MD) of the corpus callosum as a function of total PSQI score, TST, SE, and percent of time spent in each sleep stage, controlling for age and sex. Greater percent time spent in RS was significantly associated with higher FA (β = 0.41, p = 0.007) and lower MD (β = -0.30, p = 0.03). Total PSQI score, TST, SE, and time spent in LS or DS were not significantly associated with FA or MD (p>0.13). Percent time spent in REM sleep, but not quantity of light and deep sleep or subjective/objective measures of sleep quality, positively predicted white matter microstructure integrity. Our results highlight an important link between REM sleep and brain health that has the potential to improve sleep interventions in the elderly.
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