ArticleThe Laryngoscope2021
The Association Between Early Age-Related Hearing Loss and Brain β-Amyloid.
Article in The Laryngoscope, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Effect of hearing aids on cognitive functions in middle-aged and older adults with hearing loss: A systematic review and meta-analysis.Frontiers in aging neuroscience · 2022Pooled it
- Alzheimer's disease biomarkers in relation to non-cognitive domains within the intrinsic capacity framework: a narrative review.GeroScience · 2026Review
- Exploring the Relationship Between Hearing Loss and Cognitive Dysfunction from the Perspective of Molecular Mechanisms.Biomolecules · 2026Review
- Network Meta-Analysis of Cognitive Impairment and miRNA Expression in Alzheimer's Disease Patients with Hearing Loss: A Systematic Review and Cross-Validation.Journal of clinical medicine · 2026Review
- Hearing Loss Among Older Adults: Epidemiology, Disparities, and Gaps in Research.Annual review of public health · 2026Review
- Hearing Loss and Discrimination: Evidence of Intersectionality in the All of Us Research Program.The Laryngoscope · 2025Article
- Voice Disorders and Hearing Loss May Be Additive Risk Factors for Depression in a National Cohort.The Laryngoscope · 2024Article
- Hearing Loss and Reduced Income Growth: A Longitudinal Socioeconomic Analysis.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2024Observational
- GDF1 ameliorates cognitive impairment induced by hearing loss.Nature aging · 2024Article
- Age-related hearing loss is not linked to cerebrospinal fluid levels of β-amyloid or p-tau181.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Evaluation of glymphatic system activity by diffusion tensor image analysis along the perivascular space in presbycusis.CNS neuroscience & therapeutics · 2024Article
- Predicting Brain Amyloid Status Using the National Institute of Health Toolbox (NIHTB) for Assessment of Neurological and Behavioral Function.The journal of prevention of Alzheimer's disease · 2024Article
- Sensorineural hearing loss and cognitive impairment: three hypotheses.Frontiers in aging neuroscience · 2024Review
- Hearing loss is associated with decreased default-mode network connectivity in individuals with mild cognitive impairment.Neuroimage. Reports · 2023Article
- Age-related hearing loss and dementia-related neuropathology: An analysis of the United Kingdom brains for dementia research cohort.Brain pathology (Zurich, Switzerland) · 2023Article
- Hearing, β-Amyloid Deposition and Cognitive Test Performance in Black and White Older Adults: The ARIC-PET Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Association of Hearing Loss With Anatomical and Functional Connectivity in Patients With Mild Cognitive Impairment.JAMA otolaryngology-- head & neck surgery · 2023Article
- Association Between Hearing Loss and Multiple Negative Emotional States in the US Hispanic Population.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2023Article
- Global characteristics and trends of presbycusis research from 2002 to 2021: a bibliometric study.American journal of translational research · 2023Article
- Degree centrality and functional connections in presbycusis with and without cognitive impairments.Brain imaging and behavior · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectives/hypothesisTo analyze the association between early audiometric age-related hearing loss and brain β-amyloid, the pathologic hallmark of Alzheimer's disease (AD). STUDY
designCross-sectional analysis of a prospective cohort study.
methodsA cross-sectional analysis was performed on 98 participants in a cohort study of hearing and brain biomarkers of AD. The primary outcome was whole brain β-amyloid standardized uptake value ratio (SUVR) on positron emission tomography (PET). The exposure was hearing, as measured by either pure-tone average or word recognition score in the better ear. Covariates included age, gender, education, cardiovascular disease, and hearing aid use. Linear regression was performed to analyze the association between β-amyloid and hearing, adjusting for potentially confounding covariates.
resultsThe mean age ± standard deviation was 64.6 ± 3.5 years. In multivariable regression, adjusting for demographics, education, cardiovascular disease, and hearing aid use, whole brain β-amyloid SUVR increased by 0.029 (95% confidence interval [CI]: 0.003-0.056) for every 10 dB increase in pure-tone average (P = .030). Similarly, whole brain β-amyloid SUVR increased by 0.061 (95% CI: 0.009-0.112) for every 10% increase in word recognition score (P = .012).
conclusionsWorsening hearing was associated with higher β-amyloid burden, a pathologic hallmark of AD, measured in vivo with PET scans. LEVEL OF EVIDENCE: 3 Laryngoscope, 131:633-638, 2021.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.