ArticleHuman reproduction (Oxford, England)2020
Time as an outcome measure in fertility-related clinical studies: long-awaited.
Article in Human reproduction (Oxford, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05362734 (Freeze All Strategy Versus Fresh Embryo Transfer After GnRH Analogue Trigger), which is not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Freeze All Strategy Versus Fresh Embryo Transfer After GnRH Analogue Trigger
Who cites it
15 citing papers in PubMed.
- When Randomization Assigns a Starting Strategy: An Estimand-Led Framework for Frozen Embryo Transfer Trials.Therapeutic innovation & regulatory science · 2026Article
- When similar live birth rates do not mean protocol equivalence in frozen embryo transfer.Journal of assisted reproduction and genetics · 2026Article
- Probiotics as Microbiome Modulators in Male Infertility: Rethinking Dysbiosis Across the Gut-Testis Axis.Journal of personalized medicine · 2026Review
- Optimizing family building in women of advanced reproductive age: a Faster-Fewer-and-Finished approach.Frontiers in endocrinology · 2026Review
- The Long Path to Motherhood: Personal Growth and Well-Being During Medically Assisted Reproduction.Behavioral sciences (Basel, Switzerland) · 2025Article
- The most appropriate indicators of successful ovarian stimulation.Reproductive biology and endocrinology : RB&E · 2025Review
- Assessing the uptake of infertility core outcome set in IVF randomized controlled trials.Human reproduction (Oxford, England) · 2025Article
- Time to live birth: towards a common agreement.Journal of assisted reproduction and genetics · 2023Article
- Qualitative evaluation of the acceptability and feasibility among healthcare professionals and patients of an ART multi-cycle treatment planning and continuation intervention prototype.Human reproduction (Oxford, England) · 2023Article
- A blended preconception lifestyle programme for couples undergoing IVF: lessons learned from a multicentre randomized controlled trial.Human reproduction open · 2023Article
- Life on pause: An analysis of UK fertility patients' coping mechanisms after the cancellation of fertility treatment due to COVID-19.Journal of health psychology · 2022Article
- Fertility technologies and how to optimize laboratory performance to support the shortening of time to birth of a healthy singleton: a Delphi consensus.Journal of assisted reproduction and genetics · 2021Article
- Study design flaws and statistical challenges in evaluating fertility treatments.Reproduction & fertility · 2021Review
- The Livebirth Rate PerFrontiers in endocrinology · 2021Article
- Improving Reporting of Clinical Studies Using the POSEIDON Criteria: POSORT Guidelines.Frontiers in endocrinology · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Time taken to achieve a live birth is an important consideration that is central to managing patient expectations during infertility treatment. However, time-related endpoints are not reported as standard in the majority of fertility-related clinical studies and there is no internationally recognized consensus definition for such endpoints. There is, therefore, a need for meaningful discussions around the selection of appropriate time-related treatment outcome measures for studies evaluating fertility treatments that will be relevant to diverse stakeholders (e.g. patients, healthcare professionals, clinical scientists, authorities and industry). Here, we provide a proposal for the evaluation of time-related outcome measures in fertility-related clinical studies, alongside associated definitions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.