Evidence map›Paper›PMID 32644039›Full record

ArticleeLife2020

Cell lineage-dependent chiral actomyosin flows drive cellular rearrangements in early

Lokesh G Pimpale, Teije C Middelkoop, Alexander Mietke, Stephan W Grill

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Asymmetric distribution of actin-related proteins in the earlybioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Contractile forces direct the chiral swirling of minimal cell collectives.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Article
  7. Left-right symmetry breaking: learning from the chicken.Frontiers in cell and developmental biology · 2025
    Review
  8. Article
  9. A cytokinetic ring-driven cell rotation achieves Hertwig's rule in early development.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Article
  11. Friction patterns guide actin network contraction.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  12. Article
  13. Article
  14. Biochemical and mechanical regulation of actin dynamics.Nature reviews. Molecular cell biology · 2022
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. CYK-1/Formin activation in cortical RhoA signaling centers promotes organismal left-right symmetry breaking.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  20. Wnt Signaling Induces Asymmetric Dynamics in the Actomyosin Cortex of theFrontiers in cell and developmental biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Lokesh G PimpaleMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.ORCID 0000-0001-6145-1516
Teije C MiddelkoopMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.ORCID 0000-0002-0346-6143
Alexander MietkeMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.ORCID 0000-0003-1170-2406
Stephan W GrillMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.ORCID 0000-0002-2290-5826
Max Planck Institute of Molecular Cell Biology and Genetics · DEMax Planck Institute for the Physics of Complex Systems · DE

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
DFG GR 3271/2DFG GR 3271/4DFG GR 624 3271/3DFG GSC 97DFG SPP 1782Dutch Research Council (NWO) Rubicon fellowship 825.15.010Dutch Research Council Rubicon fellowship 825.15.010EMBO long-term fellowship ALTF 1033-2015European Research Council 281903European Research Council 742712European Union's Horizon 2020 research and innovation program - Marie Sklodowska-Curie Grant 641639NIH HHS P40 OD010440
6 · The paper itself

Abstract

Proper positioning of cells is essential for many aspects of development. Daughter cell positions can be specified via orienting the cell division axis during cytokinesis. Rotatory actomyosin flows during division have been implied in specifying and reorienting the cell division axis, but how general such reorientation events are, and how they are controlled, remains unclear. We followed the first nine divisions of

Indexed as

Cell DivisionCell LineageActomyosinAnimalsBiochemical PhenomenaCaenorhabditis elegansEmbryo, NonmammalianActomyosinactive chiral matteractomyosin flowsC. eleganscell lineagechiralitycytokinesisdevelopmental biologyphysics of living systemsspindle skew

Identifiers

PMID32644039
PMCPMC7394549
OpenAlexW3085722310

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.