ArticleProceedings of the National Academy of Sciences of the United States of America1988
Functional diversity of gro gene expression in human fibroblasts and mammary epithelial cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 86 citations in OpenAlex.
- Identifying differentiation markers between dermal fibroblasts and adipose-derived mesenchymal stromal cells (AD-MSCs) in human visceral and subcutaneous tissues using single-cell transcriptomics.Stem cell research & therapy · 2025Article
- Protective role of commensals against Clostridium difficile infection via an IL-1β-mediated positive-feedback loop.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- From mice to humans: identification of commonly deregulated genes in mammary cancer via comparative SAGE studies.Cancer research · 2004Article
- Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response, involving LBP, CD14 and STAT3.Breast cancer research : BCR · 2004Article
- Expression of interleukin-8 by human melanoma cells up-regulates MMP-2 activity and increases tumor growth and metastasis.The American journal of pathology · 1997Article
- Expression of transcripts for two interleukin 8 receptors in human phagocytes, lymphocytes and melanoma cells.The Biochemical journal · 1993Article
- High- and low-affinity binding of GRO alpha and neutrophil-activating peptide 2 to interleukin 8 receptors on human neutrophils.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Expression of macrophage inflammatory protein-2 and KC mRNA in pulmonary inflammation.The American journal of pathology · 1992Article
- Downregulation of JE and KC genes by glucocorticoids does not prevent the G0----G1 transition in BALB/3T3 cells.Molecular and cellular biology · 1992Article
- Removal of a 3' non-coding sequence is an initial step in degradation of gro alpha mRNA and is regulated by interleukin-1.Nucleic acids research · 1992Article
- The 9E3 protein: immunolocalization in vivo and evidence for multiple forms in culture.Journal of cell science · 1992Article
- Deletion of the c-kit protooncogene in the human developmental defect piebald trait.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Wound-factor-induced and cell cycle phase-dependent expression of 9E3/CEF4, the avian gro gene.Cell regulation · 1991Article
- Post-transcriptional regulation of gro alpha, beta, gamma, and IL-8 mRNAs by IL-1 beta.Nucleic acids research · 1991Article
- Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue.Molecular and cellular biology · 1990Article
- Identification of three related human GRO genes encoding cytokine functions.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues.The Journal of experimental medicine · 1990Article
- Neutrophil-activating properties of the melanoma growth-stimulatory activity.The Journal of experimental medicine · 1990Article
- Localization of 9E3/CEF-4 in avian tissues: expression is absent in Rous sarcoma virus-induced tumors but is stimulated by injury.The Journal of cell biology · 1990Article
- A ScaI RFLP demonstrated for the GRO gene on chromosome 4.Nucleic acids research · 1989Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Previous studies of gro and related genes that are overexpressed in transformed fibroblasts suggest that gro may encode a specific growth regulator. However, DNA and protein sequence comparisons reveal relatedness to platelet factor 4 and other proteins involved in the inflammatory response. In this paper, both growth-related and cytokine-induced responses in gro gene expression are described. Human foreskin fibroblasts are shown to express approximately 10-fold elevated gro, myc, and fos mRNAs in response to serum and to phorbol 12-myristate 13-acetate stimulation, with early response kinetics indicative of growth regulation. In response to interleukin 1, however, in growing cells gro mRNA is elevated at least 100-fold but myc remains constant and fos is not expressed, suggesting a second regulatory pathway. In normal cultured mammary epithelial cells, gro is constitutively expressed, and elevated mRNA levels are induced by phorbol 12-myristate 13-acetate, but not by interleukin 1. However, most carcinoma cell lines examined do not express gro mRNA, suggesting a third function of gro as a negative growth regulator in epithelial cells.
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