ArticleMolecular plant pathology2020
Type VI secretion systems of plant-pathogenic Burkholderia glumae BGR1 play a functionally distinct role in interspecies interactions and virulence.
Article in Molecular plant pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 35 citations in OpenAlex.
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- The VgrG2 effector of Acinetobacter baumannii mediates immune evasion by repressing Csu pilus assembly and triggering phagocyte methuosis.Nature communications · 2026Article
- A Journey into Plant-Microbe Interactions: From Lab to Field for a Sustainable Agriculture.Advances in experimental medicine and biology · 2026Review
- Type VI secretion systems at the interface between bacteria and eukaryotic cells.Genetics and molecular biology · 2026Article
- Multi-omics analyses reveal the virulence differentiation underlying natural variation inApplied and environmental microbiology · 2025Article
- The two-component regulator CvsR has a small core regulonbioRxiv : the preprint server for biology · 2025Article
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- Non-adapted bacterial infection suppresses plant reproduction.Science advances · 2025Article
- Symbiotic T6SS affects horizontal transmission ofISME communications · 2025Article
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- The Role of ClpV in the Physiology and Pathogenicity ofMicroorganisms · 2024Article
- Impact of Quorum Sensing on the Virulence and Survival Traits ofPlants (Basel, Switzerland) · 2024Article
- T6SS in plant pathogens: unique mechanisms in complex hosts.Infection and immunity · 2024Review
- A type VI secretion system effector TseG of Pantoea ananatis is involved in virulence and antibacterial activity.Molecular plant pathology · 2024Article
- The role of the type VI secretion system in the stress resistance of plant-associated bacteria.Stress biology · 2024Review
- Comparative Genome Analyses Provide Insight into the Antimicrobial Activity of EndophyticMicroorganisms · 2024Article
- Exploring the comparative genome of rice pathogenFrontiers in plant science · 2024Article
- UnderstandingPlants (Basel, Switzerland) · 2023Article
- Microbiota and the plant immune system work together to defend against pathogens.Archives of microbiology · 2023Review
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Authors and funding
11 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
In the environment, bacteria show close association, such as interspecies interaction, with other bacteria as well as host organisms. The type VI secretion system (T6SS) in gram-negative bacteria is involved in bacterial competition or virulence. The plant pathogen Burkholderia glumae BGR1, causing bacterial panicle blight in rice, has four T6SS gene clusters. The presence of at least one T6SS gene cluster in an organism indicates its distinct role, like in the bacterial and eukaryotic cell targeting system. In this study, deletion mutants targeting four tssD genes, which encode the main component of T6SS needle formation, were constructed to functionally dissect the four T6SSs in B. glumae BGR1. We found that both T6SS group_4 and group_5, belonging to the eukaryotic targeting system, act independently as bacterial virulence factors toward host plants. In contrast, T6SS group_1 is involved in bacterial competition by exerting antibacterial effects. The ΔtssD1 mutant lost the antibacterial effect of T6SS group_1. The ΔtssD1 mutant showed similar virulence as the wild-type BGR1 in rice because the ΔtssD1 mutant, like the wild-type BGR1, still has key virulence factors such as toxin production towards rice. However, metagenomic analysis showed different bacterial communities in rice infected with the ΔtssD1 mutant compared to wild-type BGR1. In particular, the T6SS group_1 controls endophytic plant-associated bacteria such as Luteibacter and Dyella in rice plants and may have an advantage in competing with endophytic plant-associated bacteria for settlement inside rice plants in the environment. Thus, B. glumae BGR1 causes disease using T6SSs with functionally distinct roles.
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