ArticleHuman brain mapping2020
Nonlinear biomarker interactions in conversion from mild cognitive impairment to Alzheimer's disease.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic performance of molecular imaging methods in predicting the progression from mild cognitive impairment to dementia: an updated systematic review.European journal of nuclear medicine and molecular imaging · 2024Pooled it
- When Age Is More Than a Number: Acceleration of Brain Aging in Neurodegenerative Diseases.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Optimising brain age estimation through transfer learning: A suite of pre-trained foundation models for improved performance and generalisability in a clinical setting.Human brain mapping · 2024Article
- Revealing Individual Neuroanatomical Heterogeneity in Alzheimer Disease Using Neuroanatomical Normative Modeling.Neurology · 2023Article
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- Fast three-dimensional image generation for healthy brain aging using diffeomorphic registration.Human brain mapping · 2023Article
- Life course, genetic, and neuropathological associations with brain age in the 1946 British Birth Cohort: a population-based study.The lancet. Healthy longevity · 2022Article
- A deep learning MRI approach outperforms other biomarkers of prodromal Alzheimer's disease.Alzheimer's research & therapy · 2022Article
- Model-based stratification of progression along the Alzheimer disease continuum highlights the centrality of biomarker synergies.Alzheimer's research & therapy · 2022Article
- Altered functional hubs and connectivity in type 2 diabetes mellitus with and without mild cognitive impairment.Frontiers in neurology · 2022Article
- Artificial Intelligence for Alzheimer's Disease: Promise or Challenge?Diagnostics (Basel, Switzerland) · 2021Review
- Better Identification of Cognitive Decline With Interleukin-2 Than With Amyloid and Tau Protein Biomarkers in Amnestic Mild Cognitive Impairment.Frontiers in aging neuroscience · 2021Article
- Early MCI-to-AD Conversion Prediction Using Future Value Forecasting of Multimodal Features.Computational intelligence and neuroscience · 2021Article
- Local Brain-Age: A U-Net Model.Frontiers in aging neuroscience · 2021Article
- Article
- Nonlinear biomarker interactions in conversion from mild cognitive impairment to Alzheimer's disease.Human brain mapping · 2020Article
- Psychosocial behavioral phenotypes of racially/ethnically minoritized older adults enrolled in HABS-HD differ on neuroimaging measures of brain age gap, hippocampal volume, and cortical thickness.Alzheimer's & dementia (New York, N. Y.)Article
- Combining aperiodic 1/f slopes and brain simulation: An EEG/MEG proxy marker of excitation/inhibition imbalance in Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Multiple biomarkers can capture different facets of Alzheimer's disease. However, statistical models of biomarkers to predict outcomes in Alzheimer's rarely model nonlinear interactions between these measures. Here, we used Gaussian Processes to address this, modelling nonlinear interactions to predict progression from mild cognitive impairment (MCI) to Alzheimer's over 3 years, using Alzheimer's Disease Neuroimaging Initiative (ADNI) data. Measures included: demographics, APOE4 genotype, CSF (amyloid-β42, total tau, phosphorylated tau), [18
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.