ArticleSoft matter2020
Inflammation product effects on dilatational mechanics can trigger the Laplace instability and acute respiratory distress syndrome.
Article in Soft matter, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- How to Successfully Navigate Flatland: A Tutorial on the Rheometry of Fluid-Fluid Interfaces.Langmuir : the ACS journal of surfaces and colloids · 2026Article
- Mechanistic Insights into Pulmonary Surfactant Inactivation.Langmuir : the ACS journal of surfaces and colloids · 2026Article
- How sighing regulates pulmonary surfactant structure and its role in breathing mechanics.Science advances · 2025Article
- Thermodynamics of Surfactant-Enriched Binary-Fluid Systems.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- New experiments and models to describe soluble surfactant adsorption above and below the critical micelle concentration.Journal of colloid and interface science · 2025Article
- Phospholipase-catalyzed degradation drives domain morphology and rheology transitions in model lung surfactant monolayers.Soft matter · 2024Article
- Evolution of interfacial mechanics of lung surfactant mimics progression of acute respiratory distress syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Effect of temperature on the air-water surface mechanical behavior of water-spread block copolymer micelles.Soft matter · 2023Article
- Solvent Quality and Aggregation State of Asphaltenes on Interfacial Mechanics and Jamming Behavior at the Oil/Water Interface.Langmuir : the ACS journal of surfaces and colloids · 2023Article
- Polymer Lung Surfactants Attenuate Direct Lung Injury in Mice.ACS biomaterials science & engineering · 2023Article
- Curvature and shape relaxation in surface-viscous domains.Physical review fluids · 2023Article
- Dilatational and shear rheology of soluble and insoluble monolayers with a Langmuir trough.Journal of colloid and interface science · 2023Article
- Microtensiometer for Confocal Microscopy Visualization of Dynamic Interfaces.Journal of visualized experiments : JoVE · 2022Article
- Mechanobiology of Pulmonary Diseases: A Review of Engineering Tools to Understand Lung Mechanotransduction.Journal of biomechanical engineering · 2021Review
- Dilatational rheology of water-in-diesel fuel interfaces: effect of surfactant concentration and bulk-to-interface exchange.Soft matter · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
In the lungs, the Laplace pressure, ΔP = 2γ/R, would be higher in smaller alveoli than larger alveoli unless the surface tension, γ decreases with alveolar interfacial area, A, such that 2ε > γ in which ε = A(dγ/dA) is the dilatational modulus. In Acute Respiratory Distress Syndrome (ARDS), lipase activity due to the immune response to an underlying trauma or disease causes single chain lysolipid concentrations to increase in the alveolar fluids via hydrolysis of double-chain phospholpids in bacterial, viral, and normal cell membranes. Increasing lysolipid concentrations decrease the dilatational modulus dramatically at breathing frequencies if the soluble lysolipid has sufficient time to diffuse off the interface, causing 2ε < γ, thereby potentially inducing the "Laplace Instability", in which larger alveoli have a lower internal pressure than smaller alveoli. This can lead to uneven lung inflation, alveolar flooding, and poor gas exchange, typical symptoms of ARDS. While the ARDS lung contains a number of lipid and protein species in the alveolar fluid in addition to lysolipids, the surface activity and frequency dependent dilatational modulus of lysolipid suggest how inflammation may lead to the lung instabilities associated with ARDS. At high frequencies, even at high lysolipid concentrations, 2ε - γ > 0, which may explain the benefits ARDS patients receive from high frequency oscillatory ventilation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.