ArticleThe world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry2021
Cellular and extracellular white matter alterations indicate conversion to psychosis among individuals at clinical high-risk for psychosis.
Article in The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- The temporal dynamics of transition to psychosis in individuals at clinical high-risk (CHR-P) shows negative prognostic effects of baseline antipsychotic exposure: a meta-analysis.Translational psychiatry · 2023Pooled it
- Saturated Fatty Acids and White Matter Microstructure in Individuals With At-risk Mental State.Schizophrenia bulletin · 2026Article
- The MR neuroimaging protocol for the Accelerating Medicines Partnership® Schizophrenia Program.Schizophrenia (Heidelberg, Germany) · 2025Article
- A narrative literature review of white matter microstructure in individuals at clinical high risk for psychosis.Psychoradiology · 2025Review
- Matrix metalloproteinase 9 (MMP-9) activity, hippocampal extracellular free water, and cognitive deficits are associated with each other in early phase psychosis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Poor self-reported sleep is associated with prolonged white matter T2 relaxation in psychotic disorders.Frontiers in psychiatry · 2024Article
- Shared and distinct white matter abnormalities in adolescent-onset schizophrenia and adolescent-onset psychotic bipolar disorder.Psychological medicine · 2023Article
- The decoupling of structural and functional connectivity of auditory networks in individuals at clinical high-risk for psychosis.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2023Article
- A Review of Potential Neuroimaging Biomarkers of Schizophrenia-Risk.Journal of psychiatry and brain science · 2023Article
- White matter microstructure and sleep-wake disturbances in individuals at ultra-high risk of psychosis.Frontiers in human neuroscience · 2022Article
- Different patterns of association between white matter microstructure and plasma unsaturated fatty acids in those with high risk for psychosis and healthy participants.General psychiatry · 2022Article
- Sex-Related Differences in White Matter Asymmetry and Its Implications for Verbal Working Memory in Psychosis High-Risk State.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesIt is important to find biomarkers associated with transition to illness in individuals at clinical high-risk for psychosis (CHR). Here, we use free-water imaging, an advanced diffusion MRI technique, to identify white matter alterations in the brains of CHR subjects who subsequently develop psychosis (CHR-P) compared to those who do not (CHR-NP).
methodsTwenty-four healthy controls (HC) and 30 CHR individuals, 8 of whom converted to schizophrenia after a mean follow-up of 15.16 months, received baseline MRI scans. Maps of fractional anisotropy (FA), FA of cellular tissue (FA
resultsThere were no significant differences between HCs and the combined CHR group. However, prior to conversion, CHR-P showed widespread lower FA compared to CHR-NP (
conclusionsOur study suggests that cellular (FA
Indexed as
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What OpenQuestion holds
Registered trials
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