Evidence map›Paper›PMID 32643525›Full record

ArticlemAbs

Malignant tissues produce divergent antibody glycosylation of relevance for cancer gene therapy effectiveness.

Dominik Brücher, Vojtech Franc, Sheena N Smith, Albert J R Heck, Andreas Plückthun

Open access · goldAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in mAbs. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Dominik BrücherDepartment of Biochemistry, University of Zurich , Zurich, Switzerland.
Vojtech FrancBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht , Utrecht, The Netherlands.
Sheena N SmithDepartment of Biochemistry, University of Zurich , Zurich, Switzerland.ORCID 0000-0002-2162-7107
Albert J R HeckBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht , Utrecht, The Netherlands.ORCID 0000-0002-2405-4404
Andreas PlückthunDepartment of Biochemistry, University of Zurich , Zurich, Switzerland.ORCID 0000-0003-4191-5306
University of Zurich · CHUtrecht University · NL

Funding

Adenoviral delivery of protein-based therapeutics to the tumor microenvironmentF32CA189372 · NCI · UNIVERSITY OF ZURICH · PI SMITH, SHEENA N · 2015 to 2017
$162k
NCI NIH HHS F32 CA189372
6 · The paper itself

Abstract

Gene therapy approaches now allow for the production of therapeutic antibodies by healthy or cancerous human tissues directly

Indexed as

Genes, NeoplasmGenetic TherapyGenetic VectorsNeoplasmsAnimalsCHO CellsCricetulusGlycosylationHumansTrastuzumabTrastuzumabadenovirusantibodycancercancer gene therapygene therapyglycoproteomicsglycosylation

Identifiers

PMID32643525
PMCPMC7531505
OpenAlexW3041770796

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.