Evidence map›Paper›PMID 32643515›Full record

ArticleHuman vaccines & immunotherapeutics2021

Characterization of humoral and cellular immune features of gamma-irradiated influenza vaccine.

Fengjia Chen, Ho Seong Seo, Hyun Jung Ji, Eunji Yang, Jung Ah Choi, Jae Seung Yang, Manki Song, Seung Hyun Han, Sangyong Lim, Jae Hyang Lim and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Human vaccines & immunotherapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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  8. Radiation-InactivatedFrontiers in immunology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Fengjia ChenRadiation Research Division, Korea Atomic Energy Research Institute , Jeongeup, Republic of Korea.
Ho Seong SeoRadiation Research Division, Korea Atomic Energy Research Institute , Jeongeup, Republic of Korea.ORCID 0000-0002-7103-1344
Hyun Jung JiRadiation Research Division, Korea Atomic Energy Research Institute , Jeongeup, Republic of Korea.
Eunji YangClinical Research Laboratory, Sciences Unit, International Vaccine Institute , Seoul, Republic of Korea.
Jung Ah ChoiClinical Research Laboratory, Sciences Unit, International Vaccine Institute , Seoul, Republic of Korea.
Jae Seung YangClinical Research Laboratory, Sciences Unit, International Vaccine Institute , Seoul, Republic of Korea.ORCID 0000-0003-1243-5610
Manki SongClinical Research Laboratory, Sciences Unit, International Vaccine Institute , Seoul, Republic of Korea.
Seung Hyun HanDepartment of Oral Microbiology and Immunology, DRI, and BK21 Plus Program, School of Dentistry, Seoul National University , Seoul, Republic of Korea.
Sangyong LimRadiation Research Division, Korea Atomic Energy Research Institute , Jeongeup, Republic of Korea.ORCID 0000-0002-0359-5180
Jae Hyang LimDepartment of Microbiology, Ewha Womans University College of Medicine , Seoul, Republic of Korea.ORCID 0000-0003-0972-9271
Ki Bum AhnRadiation Research Division, Korea Atomic Energy Research Institute , Jeongeup, Republic of Korea.ORCID 0000-0003-4445-5720
International Vaccine Institute · KRKorea Atomic Energy Research Institute · KRSeoul National University · KREwha Womans University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The most widely used influenza vaccines are prepared by chemical inactivation. However, chemical, especially formalin, treatment-induced modifications of the antigenic structure of the virus are frequently associated with adverse effects including low efficacy of protection, unexpected immune responses, or exacerbation of disease. Gamma-irradiation was suggested as an alternative influenza virus inactivation method due to its great features of completely inactivating virus while not damaging the structures of protein antigens, and cross-protective ability against heterologous strains. However, immunological features of gamma radiation-inactivated influenza vaccine have not been fully understood. In this study, we aimed to investigate the humoral and cellular immune responses of gamma radiation-inactivated influenza vaccine. The gamma irradiation-inactivated influenza vaccine (RADVAX

Indexed as

Influenza VaccinesOrthomyxoviridae InfectionsAdministration, IntranasalAnimalsAntibodies, ViralCD8-Positive T-LymphocytesGamma RaysImmunity, CellularMiceMice, Inbred BALB CVaccines, InactivatedAntibodies, ViralInfluenza VaccinesVaccines, Inactivateddendritic cellsgamma-irradiationInfluenza A virusmucosal immunitywhole cell inactivated vaccine

Identifiers

PMID32643515
PMCPMC7899634
OpenAlexW3041003282

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.