ArticleJournal of advanced nursing2020
Associations between symptom severity and treatment burden in people living with HIV.
Article in Journal of advanced nursing, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Impact of Depression and HIV Symptoms on Glycemic Outcomes among Patients with HIV and Type 2 Diabetes: A Clinical Cohort Study.AIDS and behavior · 2025Article
- Symptom experience and perceived symptom manageability among people with HIV in China: a phenomenological study.Frontiers in psychology · 2025Article
- Development and validation of the perceived symptom manageability scale among people living with the human immunodeficiency virus.BMC psychology · 2024Article
- Prevalence and predictors of HIV-related disability among people living with HIV in Nigeria.The South African journal of physiotherapy · 2024Article
- Scoping review of measures of treatment burden in patients with multimorbidity: advancements and current gaps.Journal of clinical epidemiology · 2023Article
- Identifying subtypes of HIV/AIDS-related symptoms in China using latent profile analysis and symptom networks.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
aimTo examine the association between symptoms severity and treatment burden in people living with HIV.
designCorrelational, secondary analysis of data from participants diagnosed with HIV enrolled in a descriptive, cross-sectional study examining physical activity patterns.
methodsWe analysed data from 103 men and women using self-report data collected between March 2016 - February 2017. Our primary statistical analyses consisted of explanatory multivariate modelling with individual PROMIS-29 scores representing symptom severity and treatment burden measured using the Treatment Burden Questionnaire-13.
resultsGreater symptom severity was associated with higher levels of cumulative treatment burden as well as higher levels of task-specific medication and physical activity burden. Multivariate regression analyses revealed that fatigue was a risk factor of cumulative treatment burden as well as task-specific medication and physical activity treatment burden. Effect sizes of multivariate models ranged from small (0.11) to medium (0.16). Additionally, post hoc analyses showed strong correlations between fatigue and other measured symptoms.
conclusionFindings support extant treatment burden literature, including the importance of addressing symptom severity in conjunction with treatment burden screening in the clinical setting. Results also suggest clinical interventions focused on the reduction of fatigue could reduce treatment burden in people living with HIV. Strong correlations between fatigue and other symptoms indicate the potential for reducing fatigue by addressing other highly clustered symptoms, such as depression. IMPACT: People living with HIV exhibiting higher levels of fatigue are at high risk for treatment burden and poorer self-management adherence. Clinicians should consider incorporating symptom and treatment burden assessments when developing, tailoring and modifying interventions to improve self-management of HIV and other co-morbid conditions.
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