Evidence map›Paper›PMID 32643123›Full record

ArticleClinical journal of gastroenterology2020

Outcome of colorectal cancer in Diamond-Blackfan syndrome with a ribosomal protein S19 mutation.

Kazuya Kimura, Kazuhiro Shimazu, Tsutomu Toki, Momoko Misawa, Koji Fukuda, Taichi Yoshida, Daiki Taguchi, Sho Fukuda, Katunori Iijima, Naoto Takahashi and 3 more

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Clinical journal of gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Kazuya KimuraDepartment of Clinical Oncology, Graduate School of Medicine, Akita University, Hirosaki University Graduate School of Medicine, Akita, Japan.
Kazuhiro ShimazuDepartment of Clinical Oncology, Graduate School of Medicine, Akita University, Hirosaki University Graduate School of Medicine, Akita, Japan.
Tsutomu TokiDepartment of Pediatrics, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Momoko MisawaDepartment of Pathology, Akita University Hospital, Akita, Japan.
Koji FukudaDepartment of Clinical Oncology, Graduate School of Medicine, Akita University, Hirosaki University Graduate School of Medicine, Akita, Japan.
Taichi YoshidaDepartment of Clinical Oncology, Graduate School of Medicine, Akita University, Hirosaki University Graduate School of Medicine, Akita, Japan.
Daiki TaguchiDepartment of Clinical Oncology, Graduate School of Medicine, Akita University, Hirosaki University Graduate School of Medicine, Akita, Japan.
Sho FukudaDepartment of Gastroenterology and Neurology, Graduate School of Medicine, Akita University, Akita, Japan.
Katunori IijimaDepartment of Gastroenterology and Neurology, Graduate School of Medicine, Akita University, Akita, Japan.
Naoto TakahashiDepartment of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan.
Etsuro ItoDepartment of Pediatrics, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Hiroshi NanjyoDepartment of Pathology, Akita University Hospital, Akita, Japan.
Hiroyuki ShibataDepartment of Clinical Oncology, Graduate School of Medicine, Akita University, Hirosaki University Graduate School of Medicine, Akita, Japan. hiroyuki@med.akita-u.ac.jp.
Akita University · JPHirosaki University · JPAkita University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diamond-Blackfan anemia is an autosomal dominant syndrome, characterized by anemia and a predisposition for malignancies. Ribosomal proteins are responsible for this syndrome, and the incidence of colorectal cancer in patients with this syndrome is higher than the general population. This patient's Diamond-Blackfan anemia was caused by a novel ribosomal protein S19 gene mutation, and he received chemotherapy for colorectal cancer caused by it. In his cancer, ribosomal proteins S19 and TP53 were overexpressed. He received 5FU and cetuximab; however, his anemia made chemotherapy difficult, and he did not survive long. Patients with Diamond-Blackfan anemia should be screened earlier and more often for colorectal cancer than usual.

Indexed as

Anemia, Diamond-BlackfanColorectal NeoplasmsHumansMaleMutationRibosomal ProteinsRibosomal Proteinsribosomal protein S19ChemotherapyColorectal cancerDiamond–blackfan anemiaRibosomal protein S19

Identifiers

PMID32643123
OpenAlexW3040780097

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.