Evidence map›Paper›PMID 32643086›Full record

ArticleClinical oral investigations2021

Salivary and serum markers of angiogenesis in periodontitis in relation to smoking.

Çiğdem Yılmaz Şaştım, Mervi Gürsoy, Eija Könönen, Akseli Kasurinen, Susanna Norvio, Ulvi Kahraman Gürsoy, Başak Doğan

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Article in Clinical oral investigations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  7. Serum cytokines in periodontal diseases.Periodontology 2000 · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Çiğdem Yılmaz ŞaştımDepartment of Periodontology, Faculty of Dentistry, University of Marmara, 34854 Maltepe, Istanbul, Turkey.
Mervi GürsoyDepartment of Periodontology, Institute of Dentistry, University of Turku, Turku, Finland.
Eija KönönenDepartment of Periodontology, Institute of Dentistry, University of Turku, Turku, Finland.
Akseli KasurinenDepartment of Periodontology, Institute of Dentistry, University of Turku, Turku, Finland.
Susanna NorvioDepartment of Periodontology, Institute of Dentistry, University of Turku, Turku, Finland.
Ulvi Kahraman GürsoyDepartment of Periodontology, Institute of Dentistry, University of Turku, Turku, Finland.
Başak DoğanDepartment of Periodontology, Faculty of Dentistry, University of Marmara, 34854 Maltepe, Istanbul, Turkey. basakdogan@marmara.edu.tr.ORCID http://orcid.org/0000-0002-3602-4886
University of Turku · FIMaltepe University · TR

Funding

University of Turku UT2017
6 · The paper itself

Abstract

objectiveAngiogenesis is essential in maintenance of periodontal homeostasis, and it is regulated by growth factors and cytokines, including basic fibroblast growth factor (b-FGF), endoglin, platelet and endothelial cell adhesion molecule (PECAM-1), vascular endothelial growth factor (VEGF), soluble intercellular adhesion molecule-1 (sICAM-1), and soluble vascular cell adhesion molecule-1 (sVCAM-1). In this study, the salivary and serum concentrations of these angiogenesis-related proteins in relation to smoking and periodontitis were examined. MATERIAL AND

methodsFull-mouth periodontal status together with unstimulated whole saliva and serum samples was collected from 78 individuals, including 40 periodontitis patients (20 smokers and 20 nonsmokers) and 38 periodontally healthy controls (20 smokers and 18 nonsmokers). The Luminex®-xMAP™ technique was used for protein analyses.

resultsConcentrations of all tested proteins in saliva as well as VEGF in serum were significantly higher in periodontitis patients than in healthy controls. In smokers, serum concentrations of endoglin (p = 0.017) and sICAM-1 (p = 0.001) were elevated in comparison to nonsmokers. After adjusting for smoking and gender, periodontitis associated significantly with salivary concentrations of b-FGF, PECAM-1, VEGF, sICAM-1, and sVCAM-1 (p < 0.01).

conclusionTaken together, salivary concentrations of b-FGF, PECAM-1, and VEGF associate with periodontitis. The suppressive effect of smoking on salivary marker levels is limited to periodontitis patients only. CLINICAL RELEVANCE: Smoking-related suppression of salivary marker levels is observed only in periodontitis patients.

Indexed as

PeriodontitisSmokingBiomarkersHumansIntercellular Adhesion Molecule-1SalivaVascular Endothelial Growth Factor ABiomarkersIntercellular Adhesion Molecule-1Vascular Endothelial Growth Factor ABasic fibroblast growth factorEndoglinIntercellular adhesion molecule-1Platelet and endothelial cell adhesion molecule-1Vascular cell adhesion molecule-1Vascular endothelial growth factor

Identifiers

PMID32643086
OpenAlexW2976630144

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.