Evidence map›Paper›PMID 32643007›Full record

ArticleClinical & experimental metastasis2020

CT based quantitative measures of the stability of fractured metastatically involved vertebrae treated with spine stereotactic body radiotherapy.

Michael Hardisty, Trinette Wright, Mikki Campbell, Mikhail Burke, Eshetu Atenafu, Monica Cawricz, Curtis Caldwell, Albert Yee, Arjun Sahgal, Cari Whyne

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical & experimental metastasis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Michael HardistySunnybrook Research Institute, Toronto, ON, Canada. michael.hardisty@sunnybrook.ca.ORCID http://orcid.org/0000-0002-8941-3543
Trinette WrightSunnybrook Research Institute, Toronto, ON, Canada.
Mikki CampbellDepartment of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Mikhail BurkeSunnybrook Research Institute, Toronto, ON, Canada.
Eshetu AtenafuBiostatistics Department, University Health Network, Toronto, ON, Canada.
Monica CawriczDepartment of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Curtis CaldwellSunnybrook Research Institute, Toronto, ON, Canada.
Albert YeeSunnybrook Research Institute, Toronto, ON, Canada.
Arjun SahgalSunnybrook Research Institute, Toronto, ON, Canada.
Cari WhyneSunnybrook Research Institute, Toronto, ON, Canada.
Sunnybrook Health Science Centre · CASunnybrook Hospital · CAUniversity of Toronto · CASt. Michael's Hospital · CAUniversity Health Network · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mechanical instability secondary to vertebral metastases can lead to pathologic vertebral compression fracture (VCF) mechanical pain, neurological compromise, and the need for surgical stabilization. Stereotactic body radiation therapy (SBRT) as a treatment for spinal metastases is effective for pain and local tumor control, it has been associated with an increased risk of VCF. This study quantified computed tomography (CT) based stability measures in metastatic vertebrae with VCF treated with spine SBRT. It was hypothesized that semi-automated quantification of VCF based on CT metrics would be related to clinical outcomes. 128 SBRT treated spinal metastases patients were identified from a prospective database. Of these, 18 vertebral segments were identified with a VCF post-SBRT. A semi-automated system for quantifying VCF was developed based on CT imaging before and after SBRT. The system identified and segmented SBRT treated vertebral bodies, calculated stability metrics at single time points and changes over time. In the vertebrae that developed a new (n = 7) or progressive (n = 11) VCF following SBRT, the median time to VCF/VCF progression was 1.74 months (range 0.53-7.79 months). Fractured thoracolumbar vertebrae that went on to be stabilized (cemented and/or instrumented), had greater fractured vertebral body volume progression over time (12%) compared to those not stabilized (0.4%, p < 0.05). Neither the spinal instability neoplastic score (SINS) or any single timepoint stability metrics in post-hoc analyses correlated with future stabilization. This pilot study presents a quantitative semi-automated method assessing fractured thoracolumbar vertebrae based on CT. Increased fractured vertebral body volume progression post-SBRT was shown to predict those patients who were subsequently stabilized, motivating study of methods that assess temporal radiological changes toward augmenting existing clinical management in the metastatic spine.

Indexed as

AdultAgedFemaleFollow-Up StudiesFractures, CompressionHumansMaleMiddle AgedNeoplasmsPilot ProjectsPrognosisRadiosurgeryRetrospective StudiesRisk FactorsSpinal FracturesSpinal NeoplasmsBone metastasesComputed tomographyImage-based biomarkersSpineStereotactic body radiotherapyVertebral compression fractureVertebral metastases

Identifiers

PMID32643007
OpenAlexW3042096964

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.