ArticleCerebellum (London, England)2020
Abnormal Cerebellar Volume in Patients with Remitted Major Depression with Persistent Cognitive Deficits.
Article in Cerebellum (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Meta-Analysis of Brain Volumetric Abnormalities in Patients with Remitted Major Depressive Disorder.Depression and anxiety · 2024Pooled it
- Left Cerebellar-Right Frontal Uncoupling in Female First-Episode Major Depressive Disorder: Synaptic Evidence From [CNS neuroscience & therapeutics · 2026Article
- Structural imaging predictors of ketamine response in treatment-resistant depression: a machine learning approach.Translational psychiatry · 2026Article
- Cerebellar gray matter volume difference in first-episode bipolar and unipolar depression.BMC psychiatry · 2026Article
- Associations between cerebellum and major psychiatric disorders: a bidirectional Mendelian randomization study.European archives of psychiatry and clinical neuroscience · 2026Article
- Uncovering the genetic underpinnings for different psychiatric disorder combinations.Psychological medicine · 2025Article
- Family history, inflammation, and cerebellum in major depression: a combined VBM and dynamic functional connectivity study.Translational psychiatry · 2025Article
- Effects of depression and anxiety symptoms on cognitive inhibition: A cross-sectional study of structural and functional MRI evidence.Medicine · 2025Observational
- Review
- Aerobic exercise reverses the NF-κB/NLRP3 inflammasome/5-HT pathway by upregulating irisin to alleviate post-stroke depression.Annals of translational medicine · 2022Article
- The Predictive Potential of Altered Voxel-Based Morphometry in Severely Obese Patients With Meibomian Gland Dysfunction.Frontiers in neuroscience · 2022Article
- TRPV1 Responses in the Cerebellum Lobules VI, VII, VIII Using Electroacupuncture Treatment for Chronic Pain and Depression Comorbidity in a Murine Model.International journal of molecular sciences · 2021Article
- In Search of Molecular Markers for Cerebellar Neurons.International journal of molecular sciences · 2021Review
- The critical need to develop tools assessing cerebellar reserve for the delivery and assessment of non-invasive cerebellar stimulation.Cerebellum & ataxias · 2021Article
- Structural and Functional Deficits in Patients with Poststroke Dementia: A Multimodal MRI Study.Neural plasticity · 2021Article
- Distinct Features of Cerebral Blood Flow and Spontaneous Neural Activity as Integrated Predictors of Early Response to Antidepressants.Frontiers in psychiatry · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Cerebellar involvement in major depressive disorder (MDD) has been demonstrated by a growing number of studies, but it is unknown whether cognitive functioning in depressed individuals is related to cerebellar gray matter volume (GMV) abnormalities. Impaired attention and executive dysfunction are characteristic cognitive deficits in MDD, and critically, they often persist despite remission of mood symptoms. In this study, we investigated cerebellar GMV in patients with remitted MDD (rMDD) that showed persistent cognitive impairment. We applied cerebellum-optimized voxel-based morphometry in 37 patients with rMDD and with cognitive deficits, in 12 patients with rMDD and without cognitive deficits, and in 36 healthy controls (HC). Compared with HC, rMDD patients with cognitive deficits had lower GMV in left area VIIA, crus II, and in vermal area VIIB. In patients with rMDD, regression analyses demonstrated significant associations between GMV reductions in both regions and impaired attention and executive dysfunction. Compared with HC, patients without cognitive deficits showed increased GMV in bilateral area VIIIB. This study supports cerebellar contributions to the cognitive dimension of MDD. The data also point towards cerebellar area VII as a potential target for non-invasive brain stimulation to treat cognitive deficits related to MDD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.